Solid/Semi-Solid Dosage

Progress in equipment availability, process analytical technology, and advanced process control aids ongoing development of continuous solid-dosage manufacturing processes.

An interview with Doug Hausner, C-SOPS, about continuous manufacturing

The Manesty TPR 500 tablet press from Bosch Packaging Technology increases output and features a hygienic design.

Experts share insights on how product appearance such as size, shape, color, and imprint can make a difference in reducing medication errors.

Lifecycle management opportunities are impacting the development of controlled-release technologies for solid-dosage drugs.

Doug Hausner, Engineering Research Center for Structured Organic Particulate Systems, Rutgers University discusses continuous manufacturing for solid-dosage drug production.

The author discusses various aspects of the hot-melt extrusion process and outlines a practical approach to scale-up.

The authors describe how modular systems can be applied to continuous solid-dosage and nutraceutical manufacturing.

Charlie Martin, Leistritz Extrusion, describes hot-melt extrusion manufacturing processes and advances.

The author examines the effect of compaction force, gap width, and sieve setup on granule size.

A study investigated the influence and correlation of critical process parameters for the optimization of in-process curing.

The selection of excipients is important in generic formulations due to the impact it has on the risk and performance of generic drugs.

Catalent Pharma Solutions recently launched several new softgel product developments, all of which solve a delivery problem, while offering IP advantages to drug manufacturers.

Crystal Pharmatech selects Freeslate for its CM Protege PharmD System.

Aesica has successfully completed the validation of its high capacity manufacturing facility in Queenborough, UK, for commercial production. The

Quality-by-design principles enhance a thorough understanding of both product and process technology, which is needed for optimization of solid-dosage manufacturing, including processes for improving solubility, such as hot-melt extrusion, softgels, and liquid-filled capsules.

Capsule filler

Speedy Filler Produces 200,000 capsules/hr

Tablet Press

Tablet Press with Fastest-in-Class Changeover

Discovery of split and broken tablets led to drug recalls.

I Holland announces service that predicts solutions for tablet sticking problems.

ALpHA G Capsule Filter for Single-Use Systems

Training, calibration, and preventive maintenance help prevent over-and under-weight tablets. The author discusses causes of off-weight tablets and best practices for tableting.

Operator training, preventive maintenance, and regularly scheduled calibration help prevent the manufacture of off-weight tablets.

Excipients for lowering formulation costs and improving lipid-based formulations and the use of melt-spray-congeal microsphere sachet technology for targeted controlled release attract attention at the 2013 American Association of Pharmaceutical Scientists Annual Meeting.

Tablet Tooling Coating Reduces Formulation Sticking

Analytical tests, correlated with statistical techniques, are used to predict material behavior.

Screening methods and predictive models address tenacious tablet-sticking problems.

Pliva?s new Oral Solid Forms Facility will increase Pliva's production capacities for tablets and capsules.