Solid/Semi-Solid Dosage

Metrics Inc. offers Cleantaste technology, which enables polymer coating of individual drug crystals to produce particles sized 25 um to 125 um.

The trick to taste-masking in solid dosage forms is to never let the taste buds have a chance.

Industry is moving toward closed-loop control of continuous processing.

Equipment suppliers are helping the pharmaceutical industry move towards adoption of continuous tablet production.

Loss-in-weight feeders provide high accuracy for feeding powders.

Recent advances in equipment design and operation in spraying, drying, and mixing can improve the tablet-coating process.

The tableting science anti-research (TSAR) project seeks to understand why certain formulations stick to tablet tooling.

A roundtable discussion of the challenges and innovations in tablet splitting featuring Freeman Technology, Accu-Break Pharmaceuticals, and Medelpharm.

An alternative chapter has been added to the European Pharmacopoeia for dosage uniformity.

New product reviews for February 2013.

Adopting a seven-step process to maintenance and storage improves tableting quality.

Adopting a seven-step process resolves tableting problems.

Dr. Charles Kettler, director of Natoli Scientific, looks at the challenges that tablet scoring poses to tablet manufacturers.

Tim Freeman of Freeman Technology explains how new analytical technologies have influenced quality criteria and standards for the uniformity of dosage units, and why more accurate systems are leading to greater focus on tablet scoring.

When splitting unscored tablets, the main concerns relate to API dosage control and the potential modification of time-release characteristics. PTE speaks with tableting experts Thierry Menard, Lab Manager, And Bruno Villa, President, both at Medelpharm, about how manufacturers are approaching the challenges.

Tablet splitting is a new area of focus for regulators. The FDA tells PTE more about the challenges in this area.

GlaxoSmithKline recently developed a novel technology for the formulation of modified-release tablets. The authors describe the route from development to commercialization.

Particle-engineering technologies, such as crystal design for crystallization and producting cocrystals, particle-size reduction, and amorphous solid dispersions, help to optimize delivery of a drug.

Particle-engineering technologies, such as crystal design for crystallization and producting cocrystals, particle-size reduction, and amorphous solid dispersions, help to optimize delivery of a drug.

Fluid-Bag Ltd provides comprehensive 900 and 1000 litre flexible IBC systems for liquid and semi-solid products, including filling and discharging equipment. The GMP compliant container system is designed to guarantee uniform liquid, maximise payload and minimise discharge residue (0.5% residue).

This study examines the effect and interaction of variations in hypromellose physicochemical properties.

The physical form of an API is an important consideration in formulation development. Particle-engineering technologies, such as crystal design for controlling crystallisation and producing cocrystals, particle-size reduction and amorphous solid dispersions, help to optimise delivery of a drug.

The advantages and disadvantages of hot-melt extrusion in solid dispersion formulations.

The authors investigate the tablet-coating process using a combination of different simulation techniques.

The authors describe a solid form technology platform used to optimize salt selection, cocrystallization identification and modification, or the development of a free form.

Rob Blanchard and Clive Roberts discuss the issues surrounding tablet sticking.

Industry experts share their insight on solid-dosage and sterile manufacturing.

Developments in hot-melt extrusion using twin-screw extruders to make solid-dosage drug forms.