Solid/Semi-Solid Dosage

Tablet Tooling Coating Reduces Formulation Sticking

Analytical tests, correlated with statistical techniques, are used to predict material behavior.

Screening methods and predictive models address tenacious tablet-sticking problems.

Pliva?s new Oral Solid Forms Facility will increase Pliva's production capacities for tablets and capsules.

Capsule design was developed for patients who have difficulty swallowing.

Interview of Detlev Haack, head of R&D, Hermes Pharma on the characteristics, benefits and manufacturing Methods of effervescent tablets

Stephen Tindal, Director Softgel Formulation at Catalent, talks with Pharm Tech about manufacturing issues with soft gels.

Kansas State University to build Bulk Solids Innovation Center in Salina, Kansas.

HERMES PHARMA has pioneered user-friendly dosage forms. Our effervescent and chewable tablets, lozenges, orally disintegrating granules and instant drinks are convenient to use, easy to swallow and taste good.

Analytical methods are being used to troubleshoot tablet-sticking problems and to develop screening methods and predictive models to more quickly find solutions.

An industry leader since 1933, Catalent develops and manufactures over 80% of the world's Rx softgel products with 200+ products on the market in 80+ countries.

Boehringer Ingelheim initiates a recall due to the potential for extrinsic foreign particles in the API used to manufacture Spiriva Handihaler (tiotropium bromide inhalation powder) capsules.

Foam granulation is much easier to control under mechanical dispersion conditions, which is where most industrial processes operate.

Sanofi and POZEN sign a license agreement for the commercialization of omeprazole and aspirin combination product.

The Bosspak VTC 100 electronic tablet and capsule counter from Romaco?s is designed to fill pharmaceutical solids or food supplements into bottles at high speed.

Case studies on the manufacture of a bluk powder and the development of a tablet show the application of QbD principles.

Direct tablet compression is simpler than wet or dry granulation, but obtaining the right flow properties to ensure good compaction and uniform drug distribution can be a challenge. Porous silica gel, when used as a glidant, can address these issues.

Reversible nanoencapsulation technology may make it possible to deliver high molecular weight drugs directly to target cancer cells, increasing efficacy and reducing side effects.

Experts, including researchers at I Holland, Natoli, and Rutgers University’s Engineering Research Center for Structured Organic Particulate Systems, are seeking a greater understanding of the fundamental causes of tablet sticking and are developing predictive models to more quickly find solutions to specific sticking problems.

Rapid screening of critical API properties can quickly identify the best approach for increasing bioavailability.

Almac introduces handling and bottling capabilities in EU and US headquarters.

Risk management guides decisions in facility design and operation for highly potent drugs.

The lipid-based method provides a tool for delivery of highly potent, poorly soluble, and unstable APIs. And new in-process capsule printing and shell technologies expand softgels’ applications further.

The Fluid Air Tablet Coating System consists of a modular air atomizing manifold, liquid-delivery skid, and Batch Architect process controls.

Models and modeling software gain a foothold in solid-dosage manufacturing process design.

Crushing, fracturing, and bending tests quantify hardness.

Greater automation and the adoption of solid versus perforated pans are some recent advances.

Dynamic testing and advances in shear testing provide better insight into powder physical properties and external variables that affect powder behavior.

Crushing, fracturing, and bending tests quantify hardness.

Drug manufacturers today are increasingly challenged to find new, effective methods for the delivery of active pharmaceutical ingredients, and many are discovering that orally disintegrating technologies can help.