Manufacturing, Solid Dosage Drugs

Elizabeth Scheu & Kniss will supply replacement parts for Bosch capsule filling machines.

WuXi PharmaTech and TruTag Technologies successfully applied and detected TruTag's edible microtags on solid-dosage drug products and found no effect on dissolution.

A study of root cause in stability samples suggests the need for tighter control of the sodium lauryl sulfate manufacturing processes.

Sepha's VisionScan Max can leak-test full production batches of blister packs.

Vacuum-conveying conditions for powders and other free-flowing solid forms can be simulated in Volkmann's new laboratory.

ACG Worldwide discusses current and future uses of capsules in a video interview with Pharmaceutical Technology.

PAT holds the key to real-time quality assurance and consistent product quality in pharmaceutical manufacturing.

Appropriate feeding equipment can be selected to meet the challenges of dosing powders that are sticky or do not flow well.

Economic benefits, equipment availability, research results, and FDA support are driving progress in continuous processing.

Innovations for tablet tooling and presses improve quality and productivity.

In-silico design facilitates process optimization and evaluation of process control strategies.

A drug-product manufacturing classification system (MCS) for oral solid-dosage forms is proposed by an Academy of Pharmaceutical Sciences working group.

Penn Pharma's equipment addition meets growing need for continuous dry granulation and for handling of highly potent drugs.

Innovative equipment, analytical techniques, software, and modeling systems are improving the tableting process.

Analytical technologies must accurately identify and measure the critical material attributes of APIs and excipients.

Ionic liquid technologies offer a new way to improve bioavailability.

New cellulosic polymers have been shown to improve solubility in these key amorphous solid dispersion processes.

MG America's TEKNA Capsule Filler has advanced controls to reduce powder loss and maintain optimal performance.

FDA funded projects at Rutgers' C-SOPS and at UMass Lowell to develop flow-sheet model algorithms for use in risk assessment, and start-up company Continuus Pharmaceuticals is making progress on their integrated system.

The final article of this series will look at the last two steps of the PharmaCare seven-step process?Lubricate and Store.

Solving the problem of tablet spots or specks involves prevention and thorough investigation.

Over the last three weeks, we have been looking at each step and the benefit of adopting the process. This week, we look at Step 4, Measure.

Although the source of spots and specks on tablets is sometimes difficult to identify, following good maintenance and manufacturing practices can help solve or even prevent the problem.

As the second part of this series, we look at the importance of ?assessing? the punches and dies to check their condition and how this step may help avoid any problems that may occur during tablet manufacture.

Capsugel gives lead users access to intrinsically enteric capsule technology and support services.

A G-CON, GEA, and Pfizer collaboration developed a PCMM (portable, continuous, miniature, and modular) system to produce oral solid-dosage drugs.

This review highlights relevant physicochemical drug properties and formulation design considerations critical to quality and performance of the sublingual tablets.

Many factors can contribute to tablet manufacturing problems. Tablet tooling failures are generally the result of one, or a combination of issues.

PharmaSpray delivers a consistent, validatable amount of dry lubricant.