Manufacturing Equipment, Solid Dose Drugs

MG America’s Extrudor system for its capsule filling equipment uses only one dosing disk per capsule size for all dosages.

Fette Compacting introduced its next-generation platform of tableting equipment with the F10i for small batches.

At-line NIR measurements can replace a laboratory HPLC measurement for API content in oral solid-dosage drug manufacturing.

Homogeneity of the powder blend is crucial for solid-dosage drug manufacturing.

A presentation at the Leistritz Pharmaceutical-Nutraceutical Extrusion Seminar explained how simulation tools benefit the development process.

The ChargePoint Single Use Passive and ChargeBag create a single-use system for contained and sterile transfer of pharmaceutical powders between process steps or facilities.

The UK’s Centre for Process Innovation is collaborating with partners GSK and AstraZeneca to establish a continuous wet granulation manufacturing facility for small-scale development of oral solid-dosage pharmaceuticals.

3D printing offers a new design freedom for bio/pharmaceutical manufacturing: whether for “printing” a solid-dosage drug or for creating a piece of equipment for bio/pharmaceutical laboratories or manufacturing facilities.

In OSD continuous manufacturing, flexible batch sizes can optimize supply, but equipment and processing challenges are still being addressed.

When specifying an automated powder transfer system for vacuum conveying of pharmaceutical powders, consider material properties, facility constraints, and designs to mitigate explosion.

Sticking and picking are common problems in tablet manufacturing. Considering tablet compression issues before tablet designs are finalized can prevent unanticipated problems during scale-up and full-scale production.

Flexibility and well considered manufacturing approaches could help tablet manufacturers face the increasing pressure resulting from the shifting bio/pharma development landscape.

FDA guidance on quality considerations for continuous manufacturing should help advance implementation by providing clarity and giving companies more confidence to make investments in the new technology.

Identify the warning signs and follow best practices for refurbishment to improve tablet press yields.

Containment valves and smart monitoring can keep employees safe and improve manufacturing efficiency when handling potent APIs, intermediates, and solid-dosage drugs.

The Pulse-Flow PTA dense phase pneumatic conveying system from Gericke USA directs air or nitrogen into the pressure vessel and pipeline in timed, regular pulses that form the dry material into separate, wavelike, pulsed slugs.

Mixing Dynamics has been selected as North American representative for Italvacuum dryers and pumps.

The RK-1 continuous mixing processor from Readco Kurimoto is suited for testing formulations in continuous processing conditions.

The Gold Cone X-Flo Filter Cartridge from Camfil APC stays cleaner and lasts longer than conventional pleated filters.

At CPhI Worldwide 2018, Tom Wilson, vice president of Contract Manufacturing Operations for Pfizer Global Supply and Pfizer CentreOne Contract Manufacturing, will discuss best practices for meeting manufacturing challenges of compliance as requirements shift.

Innovative technologies, such as drug-loaded devices and 3D printing, enable advances in implantable devices and other novel dosage forms.

A twin-screw extruder can be used as a continuous wet granulator.

3D printing is being explored as a manufacturing method for on-demand, personalized medicine.

A twin-screw extruder can be used as a continuous wet granulator or as a continuous mixer for a wet gelatin mass.

Leistritz’s Twin Screw Extrusion Workshop, taking place Nov. 28–29, 2018 in Clifton and Somerville, NJ, will feature classroom sessions and extrusion demonstrations.

A process control system based on PAT can compensate for variations in particle size, resulting in more consistent coating thickness in a Wurster coating process.

Increasing dwell time can improve tablet production.

Fette Compacting’s FEC20 capsule filler for medium-sized batches is a smaller version of its FEC40 machine.

Bosch Packaging Technology’s GKF 720 capsule filling machine for small batches of hard capsules uses a fully automated, washable containment process.

The acquisition expands Micromeritics’ portfolio of products and solutions.