Manufacturing Equipment, Solid Dose Drugs

Felicity Thomas, European/Senior Editor, Pharm Tech Group, and Andy Dumelow, Head of Technical Sales, I Holland, chat about tablet tooling maintenance in this brief podcast.

A good understanding of tablet tooling and how to properly maintain these key parts will maximize lifespan of tools.

By following some fundamental steps, manufacturers can optimize their tablet tooling maintenance and resulting productivity.

Collaboration and new tools aid efforts to implement new processing technologies for small-molecule drug product manufacturing.

Smart manufacturing transforms management of tablet and capsule equipment and processes.

CDMOs offer expertise and capacity for spray drying.

Trends and technologies in pharmaceutical manufacturing were highlighted on the show floor and in the conference sessions on the INTERPHEX Innovation Stage.

Sharon Nowak, Business Development Manager, Coperion K-Tron USA Food & Pharmaceutical Industries spoke about feeding equipment in solid-dosage drug manufacturing.

Fernando Muzzio, PhD, Distinguished Professor of Chemical and Biochemical Engineering at Rutgers University, spoke about trends in continuous manufacturing of OSD drugs.

Johannes Khinast, PhD, Institute for Process and Particle Engineering in the Research Center Pharmaceutical Engineering (RCPE) at the Graz University of Technology in Austria, spoke about continuous manufacturing of OSD drugs.

Dave DiProspero, director of Pharmaceutical Process Technology at CRB, spoke about equipment trends in solid-dosage drug manufacturing.

Evolving equipment designs meet the unique needs of continuous processing techniques.

Die table segment cleaning equipment features a fixture that holds the segment within the tank and leaves the bores unobstructed.

ROSS’ Sanitary Ribbon Blenders allow operators to safely empty bags of powder through a bar grating while a contiguous vibrating tray assembly catches debris and off-spec ingredients.

New features of Syntegon’s GKF 60 capsule filler include a piezo dosing system, an Automated Process Development tool, and quick changeover to containment.

Consider best practices for manual or clean-in-place procedures.

Aprecia and Glatt investigate manufacturing technologies to widen the formulation design space for oral delivery.

ILC Dover’s soloPure flexible aseptic isolator creates a closed environment for sterile filling.

Manufacturers of oral solid dose pharmaceutical formulations need PAT tools to reduce a product’s time-to-market and increase profitability.

Understanding difficulties that can occur during manufacture and resolving them quickly can improve oral solid-dosage drug production.

Two FDA-funded projects at RCPE will look at real-time monitoring and control of drug tablet coating and developing a digital twin for drug production control.

For certain APIs, including semi-synthetic antibiotics, continuous filtration and drying improves productivity and quality.

Early adopters and equipment manufacturers refine their equipment and processes, paving the way for broader use.

Using a specific addition method to wet the powder bed in twin-screw granulation using a foam binder improves robustness for continuous solid-dosage drug product manufacturing.

The continuous manufacturing platform can be used for individual unit operations or a complete solid-dosage manufacturing line and can be integrated with third-party equipment.

Risk levels should be considered when designing containment for pharmaceutical tableting equipment to enhance operator safety.

OSD forms are popular within the industry due to the various advantages they offer, but there are specific considerations required to get the best OSD form possible.

This article examines multi-tip tool technology for pharmaceutical tablet compression and the process control and validation issues that must be carefully evaluated to assess the potential for success.

Improving operator skills using flexible, online training benefits pharmaceutical tableting operations.

CPI, the University of Strathclyde, GSK, and AstraZeneca Collaborate on a continuous direct compression digital twin for pharmaceutical formulation optimization.