Solid/Semi-Solid Dosage

Data and software identify optimum pharmaceutical packaging choices for the required shelf-life.

Using a specific addition method to wet the powder bed in twin-screw granulation using a foam binder improves robustness for continuous solid-dosage drug product manufacturing.

The continuous manufacturing platform can be used for individual unit operations or a complete solid-dosage manufacturing line and can be integrated with third-party equipment.

The correct mix of excipients is crucial to the success of fast dissolving/orally disintegrating dosage forms.

A quick look at the history of OTC dosage form development shows the importance of patient-centered innovation.

Risk levels should be considered when designing containment for pharmaceutical tableting equipment to enhance operator safety.

Understanding formulation properties early in development can prevent some costly issues later on.

OSD forms are popular within the industry due to the various advantages they offer, but there are specific considerations required to get the best OSD form possible.

This article examines multi-tip tool technology for pharmaceutical tablet compression and the process control and validation issues that must be carefully evaluated to assess the potential for success.

Tools help improve understanding of excipient risk in formulating OSD drugs.

Understanding European GMPs and new rules from China for excipients are crucial for formulating solid-dosage drugs.

Careful design, planning, and record keeping are needed for cleaning and changeover in multiproduct pharmaceutical facilities.

Advanced dynamic process control of a fluid-bed granulation process using PAT data improves product quality.

As they seek to increase the number of generics available, regulators are requiring that in-vitro and other test data be used for ANDAs, and promoting the concept of biowaivers that would allow such data to replace costly clinical studies.

Several factors must be considered when reformulating APIs for pediatric, geriatric, and other specialty patient populations.

Improving operator skills using flexible, online training benefits pharmaceutical tableting operations.

CPI, the University of Strathclyde, GSK, and AstraZeneca Collaborate on a continuous direct compression digital twin for pharmaceutical formulation optimization.

Establishing OEL data and ensuring appropriate engineering controls are crucial aspects of safe handling.

High-throughput platforms can be used to develop tertiary phase diagrams, which can be leveraged to identify the most stable SEDDS formulations and excipients for lipid-based drug delivery systems.

PSE, a supplier of advanced process modeling software and services, plans to become part of Siemens Digital Industries.

At-line NIR measurements can replace a laboratory HPLC measurement for API content in oral solid-dosage drug manufacturing.

Early adopters of continuous manufacturing approaches shared their plans and some of their experiences at the 11th annual Charles Jarowski Symposium in Industrial Pharmacy.

Marchesini Group’s Compact 12 electronic counter with HarleNIR vision system measures product and active ingredient when filling and capping bottles for tablets and capsules.

Lonza plans to implement MES software to accelerate paperless, 24/7 production of drug capsules.

Suheung’s new facility in Vietnam is dedicated to vegetarian capsule manufacturing.

An agreement with Sanofi gives Catalent access to commercial spray drying facility in Haverhill, UK.

StarTab from Colorcon was designed to ensure functionality and stability for direct compression tableting.

Expansion at the Eberbach, Germany facility includes two Vegicap encapsulation lines, printing, inspection, and packaging capabilities.

Market demand and regulatory guidance continues to promote improved medication design.

Understanding the API, delivery mechanism, and excipient functionality is essential to solving drug solubility challenges.