Formulation

Patient centricity is driving change in drug discovery and development, leading to a a new dawn in therapeutics.

How dry powder techniques can overcome limitations in biologics development and delivery to broaden routes of administration and global accessibility.

The author discusses some new applications of TPGS in the pharmaceutical field that should see this versatile excipient retain its place in the drug formulators toolbox.

One company reaches beyond traditionally-conceived male contraceptives with Vasalgel, a reversible hydrogel injectable.

Emerging new technologies and disruptive manufacturing concepts are providing new opportunities for pharmaceutical companies.

Sponsors should explore key considerations ahead of choosing a new outsourcing partner.

External expertise is beneficial in helping companies select the right tools at the right stages of development to ensure success.

There are many benefits of employing a reformulation strategy, but companies must also overcome a variety of challenges too.

Using an orthogonal approach to lipid nanoparticle analysis can increase the odds of project success.

It is argued that orthogonal quantitative methods can be used to establish primary working standards. An example details how to calculate the expanded measurement uncertainty (U) for the certified assay value by considering two orthogonal assay methods.

It is possible to overcome some of the limitations of traditional dosage forms by employing alternative drug delivery formulation strategies.

Industry is adapting to the increasing complexity and poor solubility and bioavailability of molecules in the pipeline.

The purpose of this article was to demonstrate the application of a new thermogelling matrix in the healing of wounds.

Biologics are forming a greater proportion of the development pipeline, but there are still some formulation difficulties to overcome to ensure clinical and commercial success.

Lack of toxicity data and poor physicochemical properties must be overcome.

Putting the patient at the forefront of drug development is essential, particularly to ensure medication compliance is optimized.

The right processes used with the right excipient combinations address evolving formulation needs.

Recent trends in dissolution testing have led to increased use of data integrity solutions and more biorelevant testing techniques.

Partnering with an experienced service provider can help companies unlock the commercial potential of new therapeutic approaches.

Lonza has joined IPAC-RS, providing benefits to Lonza’s inhalation- related businesses due to IPAC-RS’ global voice of the orally inhaled and nasal drug products industry.

An early formulation strategy for tablets that is simple and scalable is recommended to ensure fewer downstream problems.

The author introduces a practical approach to determining the best estimate of probability for passing multiple stage dissolution tests.

DFE Pharma, Harro Höfliger, and Sterling have announced a partnership called Inhalation Together to provide formulation services for respiratory products.

Evonik has launched new EUDRATEC technology to improve solubility and performance of oral small molecules.

Technological advances are helping shape the dosage forms of the future.

Developers need to consider key challenges when approaching accelerated formulation strategies to ensure success.

Bacteriophages could be crucial weapons in the fight against antibiotic-resistant bacteria.

BioMed X and Boehringer Ingelheim have announced the start of a new research project in brain sensor development.

In this study, researchers evaluated the colloidal microcrystalline cellulose (cMCC) suspending agent—a co-processed material of microcrystalline cellulose and sodium carboxymethyl cellulose (NaCMC)—by using a representative pharmaceutical-grade commercial version of cMCC.

A key benefit for companies when outsourcing formulation development is the broad experience they can gain from a dedicated service provider, particularly for niche markets.