Analytics

Macromolecular drugs are typically injected, but oral dosage forms are being developed to improve the treatment of gastrointestinal conditions such as inflammatory bowel disease.

The company’s next-generation ultraperformance liquid chromatography platform is designed to meet the evolving laboratory requirements for chromatographic performance.

Flow imaging microscopy can be used to identify particulates and their sources.

Open communication channels between all the parties involved is key when outsourcing analytical methods, says Susan Schniepp, distinguished fellow at Regulatory Compliance Associates.

This paper analyzes the effectiveness of histogram binning for representing particle-sizing measurements with accuracy and precision.

National Institutes of Health (NIH) researchers combine two microscope technologies to create sharper, faster images.

The new kit is expected to detect a broad spectrum of pyrogens while offering high reproducibility and sensitivity as well as eliminating the need for live animal testing.

The Amgen Foundation and Harvard University will develop LabXchange, a free online science education platform that will provide digital instruction and virtual lab experiences.

Agilent Technologies expects the acquisition to improve its current software portfolio.

The company’s new UV-1900 UV-VIS spectrophotometer incorporates features that improve usability, regulatory compliance, and performance.

The sterility test isolator (STISO) for testing aseptically filled drug products and for testing toxic aseptic drugs (STISOtox) from Metall+Plastic, a subsidiary of Optima, are modular and ergonomically designed.

The combination of translatable in-vitro and in-vivo assays, coupled with expertise in immunology and oncology helps facilitate the progression of novel oncology therapeutics from hit identification to investigational new drug submission.

The ÄKTA pilot 600 from GE Healthcare is a lightweight bench-top chromatography system suited to streamline both GMP and non-GMP everyday operations.

Aerobic bioprocesses are highly dependent upon the oxygen transfer rate (OTR) from sparged to dissolved gas. The relatively low solubility of oxygen, however, makes the choice of mixer impeller configuration a critical design factor for the bioreactor vessel. This article describes a series of experiments and computational fluid dynamics (CFD) simulations to detail the effect of mixer configuration on the efficiency and effectiveness of a bioreactor vessel with respect to blend time and mass transfer.

Advanced data analytics tools are used by industry to find the golden nuggets in historical data, to aid in process development, to fine-tune production, and to achieve long-term improvements in product quality and throughput.

High speed MALDI mass spectrometry instrumentation drives multidisciplinary membrane proteomics research.

Telstar has a dedicated process analytical technology (PAT) corner at its booth to display new developments for pharmaceutical freeze drying systems and aseptic manufacturing processes.

Dolomite Microfluidics' Drug Encapsulation System offers a complete automated system for polymer micro- and nanoparticle generation.

Dolomite Microfluidics has developed the Drug Encapsulation System to provide scientists with a simple and scalable way of encapsulating drug samples.

Eppendorf’s epMotion 5075 automated liquid handling workstation comes with features developed to meet pipetting needs of the next generation sequencing library preparation process.

Eppendorf’s ViscoTip pipette tip from its Combitips advanced line can process liquids with viscosities from 200 to 14,000 mPa-s, including glycerol 99.5%, ointments, and creams.

Airflow visualization studies, or smoke studies, confirm unidirectional airflow patterns in an aseptic processing facility.

Bioprocess understanding, the right equipment, and automation help, but multifunctional teamwork is the key to API production success.

The working acceptance limits for acceptance values (AV) are determined using the critical values at, for example, 95% coverage over the corresponding AV distributions. However, validity of such limits needs to be elaborated.

This article looks at a simple structured approach to assigning variance contributions and to assuring that the analytical procedure is fit for purpose.

Geofrey Wyatt has been named CEO and Clifford Wyatt named president of Wyatt Technology.

The company will showcase its drum-filling technology among other products and services at the upcoming ACHEMA 2018 event in Frankfurt, Germany.

The company’s investment in new laboratory equipment and personnel will strengthen its cell line development services.

The company showcased newer products and equipment for cell culture laboratories at Analytica 2018 in Munich, Germany.

Proteus Digital Health is collaborating on a pipeline of digital, oral solid-dosage drugs for various therapies, including cardiovascular and oncology drugs, based on its first NDA, which used ingestible sensors in an antipsychotic treatment.