OR WAIT null SECS
April 01, 2006
Could compounds in chocolate yield new pharmaceutical approaches to major disorders?
The discovery of suitable lead structures for new drugs from an inexhaustibly large reservoir of theoretically possible compounds is one of the biggest challenges for the pharmaceutical industry. In the last few years, combinatorial chemistry methods have been developed to synthesize a huge amount of diverse new chemical entities (NCEs), which may subsequently be tested for biological activity in vitro.
Pellets are a multiparticle, solid form of medication. The individual pellets are almost spherical with diameters usually between 100 and 2000 ?m.
March 02, 2006
Polymorph farming on a chip is a promising strategy for rapid polymorph discovery by transforming crystallization?crystal isolation?characterization into one time-efficient step.
A modified modular high-pressure system can form nanosuspensions of model compounds by individually controlling cavitation, impact, and shear forces.
Quantitative data from the literature show strong relationships among average particle size, powder densification, tensile strength, and hardness.
Letter to the Editor: Glen Jon Smith
February 16, 2006
Scientists working at the Scripps Institute have re-engineered an antibiotic drug at the molecular level...
February 01, 2006
Although physicochemical preformulation screening is practised universally within the pharmaceutical industry, physicomechanical screening is applied to a lesser extent and often only where a problem exists.
This article discusses the advantages and disadvantages of using solid-state NMR spectroscopy for the analysis of pharmaceutical solids.