Authors
Latest:
The Formulation and Evaluation of Topical Berberine-Hydrochloride ProductsThe authors sought to prepare a topical formulation of berberine hydrochloride for the effective and controlled management of inflammation and skin infections.
Latest:
What to consider when expanding businesses into North AmericaIncrease your chances of success in the biggest market in the world.
Latest:
Industry must improve sample preparation techniquesSample preparation before analysis is just as important as the analytical technique because poor sample preparation alters or skews the analytical result.
Latest:
Creating PVA copolymer capsulesWhen drugs are encapsulated, electrification (the electrostatic charge of the capsule) may sometimes cause problems, such as capsule adhesion during transportation or dispersion of the capsule content in the filling process.
Latest:
Quality by Design for analytical methods for use with orally inhaled and nasal drug productsThe design of accurate and robust analytical methodology is instrumental to developing orally inhaled and nasal drug products (OINDPs) and their appropriate control programmes.
Latest:
Managing initial recovery processes with multilayer depth filtrationMonoclonal antibodies and recombinant proteins have increased their importance and gained success as therapeutic agents in the treatment of various diseases.
Latest:
Freeze-Drying with Closed VialsThe authors present an aseptic-filling process for freeze-dried liquids using the closed-vial technology.
Latest:
Current status in buccal drug deliveryThe adequate absorption and transport of drugs in the body is part of optimal therapy. Drug administration perorally is easy, common and traditional, but occasionally alternative routes are required.
Latest:
Making data analysis leanSix sigma, process analytical technology (PAT) and related initiatives are driving greater use of statistical analysis methods to increase process understanding and improve manufacturing capabilities.
Latest:
Freeze-Drying Process Optimisation for a Small MoleculeFor true freeze-drying cycle optimisation, information on the maximum allowable product temperature during primary drying is required.
Latest:
Successful strategies for product optimization...an uninformed decision based on commercial requirements alone may, ultimately, have disastrous consequences on the efficacy of the target recombinants.
Latest:
20th Anniversary Special Feature: The time for process understandingWhen Pharmaceutical Technology Europe was established 20 years ago, PAT was not a hot topic in the industry. It was started in 2002 by FDA to modernize pharmaceutical manufacturing and increase the efficiency of manufacturing processes.
Latest:
A stability-indicating HPLC procedure for determination of diltiazem hydrochloride in extemporaneously compounded oral liquidsThe stability of drugs in solid forms such as powders, tablets and capsules is usually determined very thoroughly by the drug's manufacturer. Based on stability study data, the shelf-life of a drug substance or a drug product is assigned. In addition to dispensing solid dosage forms to patients, pharmacists are frequently asked to compound oral liquid preparations for which the shelf-life or beyond-use date are assigned based on the pharmacist's best judgment - often without the benefit of stability data.
Latest:
Formulation effects on the thermomechanical properties and permeability of free films and coating filmsUnderstanding a formulation's variable effects on its properties, especially film permeability, is key to designing a robust formulation and reducing variation of a finished product.
Latest:
Verification Methods for 198 Common Raw Materials Using a Handheld Raman SpectrometerUsing handheld Raman spectroscopy, methods were developed and evaluated for 198 substances widely used as raw materials.
Latest:
The New Digital Era for Formulation DevelopmentA new generation of interactive formulation development platforms can leave trial and error in the formulation process in the past.
Latest:
Is pharma's supply chain safe?How can any company be sure that the standards that suppliers might claim to operate, and might be able to demonstrate from time to time, are actually being practised all the time?
Latest:
Modulation of drug release from hydrophilic matricesDifferent chemistries and viscosities of HPMC can be combined to modulate release profile and, in some cases, result in a more robust formulation.
Latest:
Managing initial recovery processes with multilayer depth filtrationMonoclonal antibodies and recombinant proteins have increased their importance and gained success as therapeutic agents in the treatment of various diseases.
Latest:
The influence of superdisintegrant choice on the rate of drug dissolutionThe addition of superdisintegrants to oral solid dosage forms can improve disintegration and, in turn, drug dissolution.
Latest:
Creative Solutions in Client-CRO RelationshipsA CRO and a client company must plan strategically together to minimize and prevent possible project roadblocks.
Latest:
Laboratory Equipment QualificationA summary of the conclusions of the PhRMA Workshop on Acceptable Analytical Practices describes equipment qualification practices and guidelines that are designed to help the pharmaceutical industry be consistent in meeting core requirements.
Latest:
The Impact of Automation on Aseptic ProcessingThe authors review the role of automation in aseptic processing and describe their experience in implementing advanced technologies, including the use of isolators and robotics.
Latest:
Monitoring Granulation Drying Using Near-Infrared SpectroscopyA novel probe design that reduces the variation in powder-sample density also allows moisture and solvent levels to be accurately modelled and predicted...
Latest:
Tackling waste water with nanofiltration membranesThe pharmaceutical industry must address the release of nonbiodegradable APIs into the environment.
Latest:
USP's Semi-Hemiquinquennial MeetingA recent USP gathering generated creative suggestions for the March 2005 USP convocation.
Latest:
Elevating laboratory informatics to assist decision-makingWith pressure to cut costs, shorten the pipeline life cycle and maximize return on investment, pharmaceutical manufacturers need tools that help them improve enterprise-wide communications, reach critical decisions faster and produce timely, accurate reports on how compounds are progressing.
Latest:
Dissolution Testing For Inhaled DrugsAlthough there are no regulatory requirements or established pharmacopoeial techniques for the dissolution testing of inhaled drugs, such testing can potentially open up the opportunity to tailor formulation properties.
