Ramesh Panchagnula, PhD

Mefenamic acid has variable bioavailability and tabletting issues because of its hydrophobic nature and poor material characteristics. Recrystallization of mefenamic acid was performed from three different solvent–solvent mixtures under differing conditions. The crystals obtained were screened for the existence of new crystal properties or polymorphic forms, then characterized further.

The authors investigate whether an extrusion-spheronization proces can be used to develop a matrix-based, controlled-release formulation for a highly water-soluble drug.

Recent advances in polymer science have resulted in a wide range of commercially available polymers for use in transdermal drug delivery systems.