The Impact of Vortexing on the Particle-Size Distribution of Pharmaceuticals
If a vortex mixer produces too much energy during sample preparation for particle size analysis, the size and morphology of particles can change. A study compares the applied shear to sample suspensions of ibuprofen to observe the effects of applied shear on the particle size distribution.
Sample preparation is a crucial step during particle size analysis, especially when trying to maximize accuracy and precision. A vortex mixer is frequently used its importance may be overlooked.
If a vortex mixer produces too much energy during sample preparation for particle size analysis, the size and morphology of particles can change. A study compares the applied shear to sample suspensions of ibuprofen to observe the effects of applied shear on the particle size distribution.
Read this article in Pharmaceutical Technology's Bio/Pharma Laboratory Best Practices 2018 eBook.
Article Details
Pharmaceutical Technology
ebook: Bio/Pharma Laboratory Best Practices 2018
Vol. 42
November 2018
Pages: 42–46
Citation
When referring to this article, please cite it as G. Maj, et al., "The Impact of Vortexing on the Particle-Size Distribution of Pharmaceuticals," Pharmaceutical Technology Bio/Pharma Laboratory Best Practices eBook (November 2018).
Drug Solutions Podcast: Applying Appropriate Analytics to Drug Development
March 26th 2024In this episode of the Drug Solutions Podcast, Jan Bekker, Vice President of Business Development, Commercial and Technical Operations at BioCina, discusses the latest analytical tools and their applications in the drug development market.
