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August 01, 2013
External manufacturing plays a crucial role in pharmaceutical companies’ supply strategy. The author examines market trends for the captive and merchant global market for active pharmaceutical ingredients and intermediates.
July 18, 2013
Novel, atom-efficient routes to amides from esters and carboxylic acids for more sustainable manufacturing.
July 02, 2013
New routes enable the efficient synthesis of enantiopure sulfinamides and structurally and sterically diverse P-chiral phosphine oxides.
June 26, 2013
Cocrystals can enable the formulation of solid dosage drugs, but the FDA's final guidelines have left concerns about how their use could impact development timelines, the drug product manufacturing process, and the intellectual property position of products containing cocrystals.
May 22, 2013
Dynamic testing and advances in shear testing provide better insight into powder physical properties and external variables that affect powder behavior.
May 16, 2013
Access to extremely low and consistently controlled reaction temperatures can improve product yields and selectivities while also reducing costs.
April 10, 2013
Access to simpler and more direct methodologies for the incorporation of fluorinated substituents remains an unmet need in pharmaceutical synthesis. An analysis of recent trends in fluorination chemistry.
April 02, 2013
Continuous flow chemistry offers potential for greater control, improved safety and environmental profiles, and efficient chemical transformations.
March 02, 2013
Visual mapping can provide a particle-size distribution estimate.
February 06, 2013
As contract API manufacturers, fine-chemical producers, and pharmaceutical companies prepare to attend Informex in Anaheim this month, the state of the industry shows improving conditions in certain sectors.