Manufacturing Systems, Single-Use

Global product manager at Cytiva, Eric Corti, discusses the challenges with designing a new single-use mixing system that ensures leak-free fluid handling operations at INTERPHEX 2024.

What are the lessons gleaned from a product’s E&L lifetime?

The evolution of therapeutic modalities drives the adoption of single-use technologies.

Pharmaceutical Technology Europe® spoke with Fiona Bellot, sales director, Cellexus BioreactorSystems, at the inaugural Start-Up Market on the show floor at CPHI Barcelona 2023.

The combination of modular facilities and closed processing offers significant advantages in the production of biopharmaceuticals and is becoming a compelling option for manufacturing.

Although new single-use technologies offer the flexibility needed to overcome several challenges in ATMP production, there are many considerations and hurdles manufacturers must be aware of when scaling.

Experts outline the benefits of single-use consumables relative to traditional approaches.

Standardized risk assessment and analysis protocols facilitate the comparison of processing equipment components.

MilliporeSigma’s €130 million (USD$132 million) investment is designed to increase manufacturing capacity of single-use assemblies.

ChargePoint Technology has acquired single-use container company PuroVaso.

Flexible and efficient methods are needed for biopharmaceutical manufacturing.

The struggle to implement continuous biomanufacturing at GMP level is slowly advancing.

High Purity New England has launched its third facility, focused on single-use assemblies.

Thermo Fisher Scientific is expanding its Millersburg, Penn., site with a $40 million investment to support increased production of single-use technology for critical vaccines and biologics.

PharmTech interviewed Sartorius about SUS innovations and trends.

Training is crucial for supporting GMP operations in commercial-scale bioprocessing.

Workforce training is crucial for biopharmaceutical manufacturing.

Trends and technologies in pharmaceutical manufacturing were highlighted on the show floor and in the conference sessions on the INTERPHEX Innovation Stage.

Fujifilm is expanding its R&D footprint at its California facility.

CPC’s MicroCNX Series Connectors provide an alternative to tube welding at small tubing sizes.

Thermo Fisher Scientific plans to expand its Nashville, Tenn., site by establishing a dedicated single-use technology manufacturing facility at the site, doubling capacity.

NewAge Industries is adding cleanrooms at its Pennsylvania headquarters.

Through the acquisition, Avantor will have access to RIM’s Changzhou, China, facility, making it Avantor’s first single-use production plant in the AMEA region.

Lonza plans to invest approximately CHF 850 million (US$936 million) to build new state-of-the-art mammalian manufacturing facilities at its Visp, Switzerland, and Portsmouth, NH, sites.

Aber Instruments launched its new Futura neotf single-use biomass sensor for process fingerprinting for on-line monitoring and control of cell culture.

Avantor plans to increase its single-use manufacturing footprint by 30% and double its cleanroom space in the US and Europe.

AkesoBio’s expanded manufacturing capacity, enabled by the addition of another Cytiva FlexFactory platform, will be used to meet current and future market needs in China as well as worldwide.

ILC Dover’s soloPure flexible aseptic isolator creates a closed environment for sterile filling.

The investments are expected to double Thermo Fisher’s manufacturing capacity while creating more than 1500 jobs at 11 manufacturing sites in the Americas, Europe, and Asia.

Collaboration between equipment suppliers and users is leading to innovation and optimization in biopharmaceutical manufacturing.