Manufacturing Equipment, Fill-Finish

The document includes recommendations for the reporting and implementation of changes to container closure system components.

Corning launches a more sustainable glass vial.

WuXi STA’s new high-potency injectable line has an annual capacity of 12 million units.

This will allow industry leaders to make and sell the product, in addition to providing more choice to pharma and biotech companies.

Shifts in pharmaceutical packaging have spurred tremendous growth in the pre-filled syringe fill/finish industry.

To prepare for emerging mRNA technologies, it is necessary to adapt fill/finish and cold chain capabilities.

Steriline will be exhibiting its vial filling and capping machine (VFCM100) under double-wall isolator for aseptic filling at CPHI 2022 in Frankfurt, Germany, on Nov. 1–3, 2022.

Recipharm’s new high speed filling line, designed for pre-filled syringes and cartridges, is expected to be operational by May 2023.

Product safety and security are paramount when it comes to container closures.

BFS technology can help maintain sterility during the biologics manufacturing process.

Watson-Marlow and Franz Ziel GmbH have launched a new integrated solution to fast-track cell, gene, and biological therapies.

Grand River Aseptic Manufacturing has completed phase II of its facility expansion with the installation of two new sterile filling lines.

Exhibitors display primary packaging, secondary packaging, and machine innovations at this year’s INTERPHEX.

INCOG Biopharma has completed the construction of its cleanroom production area, marking a milestone in the completion of an overall $100 million investment in a new facility.

The continuous, aseptic fill/finish process is finding use in vaccines and biologic drugs.

Curia and the US government have entered into a cooperative agreement to expand fill/finish capability for injectable medicines.

Moderna and Thermo Fisher Scientific have formed a collaboration to leverage dedicated commercial fill/finish manufacturing capacity in the US for mRNA vaccines and therapies.

Fareva plans to use blow-fill-seal equipment and ApiJect’s prefilled injector technology to create fill/finish capacity in France.

Lonza plans to establish drug product manufacturing capabilities at is site in Guangzhou, China, to produce clinical trial and commercial supply in the country.

Aenova has announced plans to open a new new can and bottle filling production line in Cornu, Romania.

Container and equipment innovations expand applications.

The new line can fill prefilled syringes, cartridges, and vials using ready-to-use components.

Samsung Biologics plans to support the production of hundreds of millions of doses of Moderna’s vaccine to supply to markets outside of the United States beginning in the third quarter of 2021.

Under the terms of the expanded agreement, Catalent will provide Moderna with a new high-speed vial filling line until June 2023 along with inspection, labeling, cartoning, and final packaging for potential pipeline programs.

Decontamination, automation, and containment are important considerations for aseptic manufacturing in isolators.

CDMOs address the unique challenges of liquid and lyophilized forms as well as preparing for the large capacity needed for COVID-19 vaccines.

Cytiva acquired Vanrx Pharmasystems, a Canadian manufacturer of robotic aseptic filling equipment.

The company is investing in expansion at four sites in the United States, United Kingdom, and Italy, which will include construction of new facilities and addition of sterile and lyophilized filling lines.

The investment will expand and upgrade manufacturing capacity and technology for pre-fillable syringes and will also includes a new manufacturing facility in Europe.

A holistic approach to validation and quality assurance is essential.