Equipment

The emergence of new biotherapeutics is both the driver and result of innovative drug development technologies.

Consider best practices for manual or clean-in-place procedures.

Process intensification in continuous biopharmaceutical processing can change the way the equipment is used and thus affect cleaning methods.

GoSilico’s software for digital twins of downstream biopharmaceutical processes will be integrated into Cytiva.

Tosoh Bioscience introduced the TSKgel FcR-IIIA-5PW HPLC column, a semi-preparative affinity column based on a recombinant FcγRIIIA receptor ligand bonded to porous 10 µm polymethacrylate particles.

The TipFil Syringe Filler from TurboFil Packaging Machines is a benchtop syringe filling machine that offers full control of filling parameters in single or dual operation and fills at a rate of up to 12 pieces per minute.

Shimadzu released the TOC-1000e, an analyzer in the eTOC series of on-line TOC analyzers formulated for pure water applications.

The ROSS Double Planetary Mixer from Charles Ross & Son Company is available with an optional weighing system for precise measurements throughout the batching procedure.

The new line can fill prefilled syringes, cartridges, and vials using ready-to-use components.

Samsung Biologics plans to support the production of hundreds of millions of doses of Moderna’s vaccine to supply to markets outside of the United States beginning in the third quarter of 2021.

VectorY, a Netherlands-based biotechnology company, has been selected as the European winner of MilliporeSigma’s 2021 Advance Biotech Grant Program.

Advances in automation and cleanroom technology improve efficiency for small commercial quantities of aseptically filled drug products.

Certain therapeutics, such as ophthalmics, must be provided as a sterile dosage form but can pose fill/finish challenges due to the small batch sizes required and the fact that the products used are difficult to fill and of high value.

The latest news about biologics facilities includes various expansions, new locations, and acquisitions in the bio/pharmaceutical space.

The expansions will add peptide manufacturing capacity.

The semi-automated TipFil Syringe Filler from TurboFil Packaging Machines provides accurate and consistent fills.

Lonza plans to invest approximately CHF 850 million (US$936 million) to build new state-of-the-art mammalian manufacturing facilities at its Visp, Switzerland, and Portsmouth, NH, sites.

Aprecia and Glatt investigate manufacturing technologies to widen the formulation design space for oral delivery.

Aber Instruments launched its new Futura neotf single-use biomass sensor for process fingerprinting for on-line monitoring and control of cell culture.

The XPR Automatic Balance by Mettler Toledo works to reduce exposure risk and ensure precision and throughput while powder weighing in laboratories.

Inline High Shear Mixers from ROSS are suitable for a wide range of dispersion, emulsification, and homogenization requirements

Munson Machinery introduced a new Bag Dump Module for installation on the lids of bulk solid mixers, blenders, size-reduction equipment, and storage vessels to maintain the dust produced when bulk materials are dumped manually.

Avantor plans to increase its single-use manufacturing footprint by 30% and double its cleanroom space in the US and Europe.

AkesoBio’s expanded manufacturing capacity, enabled by the addition of another Cytiva FlexFactory platform, will be used to meet current and future market needs in China as well as worldwide.

The new facility, which will be Evotec’s first in Europe, will aim to offer capacity, flexibility, and quality for biotherapeutic development and manufacturing while utilizing technology that employs small, automated, highly intensified, and continuous bioprocessing operations inside autonomous cleanrooms.

Sartorius has expanded in the United Kingdom with the relocation to a new facility in Havant, Hampshire, for downstream processing equipment.

ILC Dover’s soloPure flexible aseptic isolator creates a closed environment for sterile filling.

Catalent’s new mammalian cell culture suites in Madison, Wis. use single-use bioreactor systems for CGMP clinical and commercial manufacturing.

The China National Medical Products Administration has given the company the green light to begin manufacturing commercial supply of its approved anti-PD-1 antibody, tislelizumab, at its biologics facility in Guangzhou, China.

Under the terms of the expanded agreement, Catalent will provide Moderna with a new high-speed vial filling line until June 2023 along with inspection, labeling, cartoning, and final packaging for potential pipeline programs.