A. Waseem Malick, PhD, is vice-president at the pharmaceutical and analytical research and development department of HoffmanâLa Roche Inc. (Nutley, NJ).
Effect of Formulation and Process Variables on Matrix Erosion and Drug Release from a Multiunit Erosion Matrix of a Poorly Soluble Drug
By optimizing formulation and process varibles, pellets can be prepared that can release a poorly soluble drug for 12-24 h following zero-order kinetics.