P. Ravi

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R&D president at Analytical Research & Development Department, Neuland Pharma Research, R&D Centre Bonthapally, Hyderabad.

Articles

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Determination of Related Substances in Pemetrexed Disodium (Form-IV) in Bulk Drug Samples by HPLC

K.R. Wadekar;K. Adyanth;T. Chakravarthy;S.D. Mankumare;N. Meera;P. Ravi
February 2nd 2014

The authors describe the development of a stability-indicating reverse-phase high-performance liquid chromatographic (RP?HPLC) method for the quantitative determination of potential genotoxic impurities present in pemetrexed disodium (form-IV). The chromatographic separation was achieved on a RP?HPLC column (Zorbax SB-Phenyl, Agilent) at ambient temperature with gradient elution using mobile phase A (trifluoroacetic acid [TFA] in water) and mobile phase B (TFA in acetonitrile).

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