K. Venugopal is a postgraduate student from the National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar 160 062, India, presently working at Ranbaxy Research Laboratories (Gurgaon, India).
Alteration in Dissolution Characteristics of Gelatin-Containing Formulations: A Review of the Problem, Test Methods, and Solutions
Eventual change in the dissolution characteristics of some dosage forms, which is ascribed to cross-linking of gelatin, continues to present challenges to drug manufacturers. The authors discuss the causes, mechanisms, and solutions to the problem.