Greg Paddon-Jones, PhD, is director of Product Development at Antares Health Products.

Greg Paddon-Jones

Vitamin E TPGS, or d-α-tocopheryl polyethylene glycol 1000 succinate, was first developed more than 60 years ago as a water-soluble form of naturally occurring vitamin E. Originally used to treat vitamin E deficiency in cholestatic patients, TPGS quickly attracted attention as a versatile solubilizer due to its amphiphilic nature and surfactant properties. Further application of this molecule emerged in the 1990s, when TPGS was shown to improve epithelial absorption by modulating cellular efflux. Researchers have continued to find a variety of new and exciting applications of this molecule, and TPGS has become an important tool for drug delivery formulators. This report serves to summarize some of recent innovations using TPGS for improved delivery of bioactive materials.

Emerging Applications of Vitamin E TPGS in Drug Delivery

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When referring to this article, please cite it as G. Paddon-Jones, "Emerging Applications of Vitamin E TPGS in Drug Delivery," 

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Articles

The author discusses some new applications of TPGS in the pharmaceutical field that should see this versatile excipient retain its place in the drug formulators toolbox.