Understanding Fluidized-Bed Granulation
Pharmaceutical Technology Europe
This study demonstrates the beneficial use of a spatial-filter velocimetry particle-size analyzer during granulation.
By A. Burggraeve, T. Van Den Kerkhof, M. Hellings, J.P. Remon, C. Vervaet and T. De Beer
The authors incorporated a particle-size analyser into a laboratory-scale top-spray fluid-bed granulator to monitor granule size distribution (GSD) continuously during granulation. A two-level full-factorial design was used to study the influence of several process and formulation variables on the end-product GSD, measured in-line with spatial-filter velocimetry (SFV).
This article was also published in our US sister publication Pharmaceutical Technology and can be read here.
Clinical Supply Planning in Europe - Balancing Cost, Flexibility and Time
December 19th 2024The packaging and distribution of clinical supplies is a fundamental piece to the overall success of a clinical trial, and advance preparation can help establish a more efficient supply chain. Selecting the best geographical location for those activities, however, depends on the clinical trial protocol, business decisions, and even the investigational medicinal product (IMP) being studied.
