Protein Analyzer Offers Ability to Measure Protein Titer Directly from Bioreactor
The Tridex Protein Analyzer from IDEX offers the ability to directly measure protein titer from a bioreactor in real time.
Image courtesy of IDEX
The Tridex Protein Analyzer from IDEX Health & Science offers the ability to directly measure protein titer from a bioreactor in real time. The analyzer is a compact and an easy-to-use solution for at-line titer monitoring in a bioprocess environment. It is built to ensure that at-line results directly correlate to offline high-performance liquid chromatography methodology.
The biopharma industry has long been seeking an alternative to time-consuming offline methods currently in use, and the measurement of antibody titer is a critical parameter for manufacturing biologics and biosimilars, the company reports. The Tridex Analyzer quickly delivers accurate titer measurements over a dynamic range of 0.1–10 g/L, with minimal sample manipulation for use in R&D and process development.
The Tridex Analyzer is the first protein analyzer on the market built specifically for bioprocess monitoring, according to the company. It uses a unique trap and elute technique to accurately monitor the titer in a bioreactor. It does not require chromatography expertise, specialized training, or extensive method development. The sample flowpath is completely enclosed, lending itself to the requirements of single-use bioprocessing.
The Tridex system also offers the option to connect to an automated sampling system for complete integration into a bioprocessing environment and to deliver actionable results with just a few clicks. IDEX launched the new analyzer in July 2019.
Source: IDEX Health & Science
Transformations in Drug Development for Cell and Gene Therapies
March 28th 2025As a recognized leader in immunophenotyping for clinical trials, Kevin Lang from PPD discusses how spectral flow cytometry is transforming drug development, particularly in cell and gene therapies like CAR-T. He also dives into his award-winning research, including his 2024 WRIB Poster Award-winning work, and his insights from presenting at AAPS PharmSci360.
Advancing Clinical Trials with Spectral Flow Cytometry: A Conversation with Kevin Lang
March 28th 2025As a recognized leader in immunophenotyping for clinical trials, Kevin Lang from PPD discusses how spectral flow cytometry is transforming drug development, particularly in cell and gene therapies like CAR-T. He also dives into his award-winning research, including his 2024 WRIB Poster Award-winning work, and his insights from presenting at AAPS PharmSci360.
Drug Shortages and Complying with FDA’s 21 CFR 211.110 Guidance
April 2nd 2025Susan J. Schniepp, distinguished fellow at Regulatory Compliance Associates, and Rona LeBlanc-Rivera, PhD, principal consultant, Regulatory Affairs at Regulatory Compliance Associates, answer some questions about FDA’s January 2025 21 CFR 211.110 guidance document.
