Localized treatment approaches for diabetic neuropathic pain management, like pregabalin liposomal topical formulations, offer a novel strategy by directly targeting affected areas. Liposomes enhance skin permeability and sustain drug release, delivering pregabalin efficiently to peripheral nerves while reducing systemic exposure. In a proof-of-concept study using an IVPT and a diabetic neuropathic pain rat model, improved skin penetration and significant reductions in mechanical allodynia and thermal hyperalgesia were shown.
A Discussion: In Vitro Release Testing and Its Application and Use in Generic Topical
December 18th 2024Lucy Zhou, Director of Skin Lab at CPL, discusses the importance and applications for utilizing in vitro Release Testing during development of generic topical drug compounds. Lucy dicusses how IVRT can play a critical role by saving cost and time during product development and the techniques and applications for using in vitro testing to achieve desired product outcomes.