A Comparison of Three Extrusion Systems (Part II)
The authors compare three systems of single-screw extrusion using binary formulations for their suitability for producing pellets of various formulations and under various spheronization conditions.
By Amelie Desire, Bruno Paillard, Joel Bougaret, Michel Baron and Guy Couarraze
The authors compare three systems of single-screw extrusion (i.e., radial, dome, and axial) using binary formulations (i.e., microcrystalline cellulose, and active material) for their suitability for producing pellets of various formulations and under various spheronization conditions. Pellets were characterized by their size and shape, and by their structural and mechanical properties. The experimental design showed high variation between the three extrusion systems.
This article was also published in our US sister publication Pharmaceutical Technology and can be read here.
Clinical Supply Planning in Europe - Balancing Cost, Flexibility and Time
December 19th 2024The packaging and distribution of clinical supplies is a fundamental piece to the overall success of a clinical trial, and advance preparation can help establish a more efficient supply chain. Selecting the best geographical location for those activities, however, depends on the clinical trial protocol, business decisions, and even the investigational medicinal product (IMP) being studied.
