Manufacturing, Specialty Dosage Forms

Catalent has announced the completion of a $30 million project at its facility in Limoges, France focused on biopharmaceutical development and drug product manufacturing.

CDMOs offer expertise and capacity for spray drying.

Researchers in China report test results for a microneedle patch for COVID-19 vaccine delivery.

Considering interactions and understanding regulatory requirements are crucial when developing a drug or biologic product for use with a medical device.

ImmunityBio will proceed with a Phase I/II/III trial in South Africa of their dual-antigen T-cell vaccine as a boost in participants who were previously vaccinated against COVID-19.

UltraBurst has a high disintegration speed, which is for all market segments, from prescriptions to nutraceuticals.

Aprecia and Glatt investigate manufacturing technologies to widen the formulation design space for oral delivery.

The collaboration will evaluate Nanoform’s fast dissolution nanoparticles in Aprecia’s ZipDose 3DP technology platform for buccal and oral drug delivery.

CMDO Piramal Pharma Solutions held a grand opening at a facility they acquired in Sellersville, PA.

A device manufacturing process must be carefully designed in the early stages of development to ensure success in commercial manufacturing.

Evonik opened a new facility for GMP manufacturing of bioresorbable polymers and excipients for pharmaceutical and medical applications in Birmingham, AL.

Equipment and process optimization must be considered for scaling up these developmental technologies to commercial production.

Hovione Technology worked with Harro Höfliger on powder filling of blisters for the reusable Papillon DPI.

PATH’s Microarray Patch Center of Excellence aims to accelerate transdermal patch technology for public health needs.

Catalent announces investment for its Zydis ODT technology, offering increased drug load and taste-masking capabilities.

Using a QbD approach in the development and formulation of topical products will enable the drug developer to provide a robust control strategy for manufacturing.

Fette Compacting America has introduced the FEC20 Capsule Filling Machine, capable of producing up to 200,000 capsules per hour, to the North American market.

Transdermal patch design, materials, and manufacturing variables, as well as drug formulation and interactions between the API and the adhesive, can affect adhesion and drug delivery.

Virpax’s Patch-in-a-Can technology delivers pain medication using a metered-dose spray film.

Drug and adhesive formulation are crucial to the development of microneedle patches for pharmaceutical transdermal delivery systems.

Innovative technologies, such as drug-loaded devices and 3D printing, enable advances in implantable devices and other novel dosage forms.

3D printing is being explored as a manufacturing method for on-demand, personalized medicine.

This article examines IVBE testing requirements for topical creams and explores some of the analytical techniques necessary.

Particle engineering using jet milling or spray drying can be used to obtain appropriate particle characteristics for inhalation drug products.

Puncture and aerosolization tests measure the effectiveness of hard-shell capsules used in dry powder inhalers (DPIs) for inhaled drug products.

A single-use DPI from Perlen Packaging, which offers lower-cost production and a more affordable device for emerging markets, won a 2017 CPhI Pharma Award.

Aero Pump’s preservative-free Multidose Eye Dropper System with SideActuationDevice received the CPhI Pharma Award for Excellence in Pharma: Packaging.

A QbD approach can address manufacturing complexities in transdermal patch manufacturing.

Aptar now manufactures its child-resistant pump, designed to meet US CPC requirements, at its facility in Congers, New York.

Transdermal and inhaled/nasal delivery provide alternative routes of administration for macromolecules.