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January 01, 2013
Tim Freeman of Freeman Technology explains how new analytical technologies have influenced quality criteria and standards for the uniformity of dosage units, and why more accurate systems are leading to greater focus on tablet scoring.
When splitting unscored tablets, the main concerns relate to API dosage control and the potential modification of time-release characteristics. PTE speaks with tableting experts Thierry Menard, Lab Manager, And Bruno Villa, President, both at Medelpharm, about how manufacturers are approaching the challenges.
December 02, 2012
GlaxoSmithKline recently developed a novel technology for the formulation of modified-release tablets. The authors describe the route from development to commercialization.
October 02, 2012
Fluid-Bag Ltd provides comprehensive 900 and 1000 litre flexible IBC systems for liquid and semi-solid products, including filling and discharging equipment. The GMP compliant container system is designed to guarantee uniform liquid, maximise payload and minimise discharge residue (0.5% residue).
October 01, 2012
The physical form of an API is an important consideration in formulation development. Particle-engineering technologies, such as crystal design for controlling crystallisation and producing cocrystals, particle-size reduction and amorphous solid dispersions, help to optimise delivery of a drug.
September 02, 2012
The advantages and disadvantages of hot-melt extrusion in solid dispersion formulations.
September 01, 2012
The authors describe a solid form technology platform used to optimize salt selection, cocrystallization identification and modification, or the development of a free form.
Rob Blanchard and Clive Roberts discuss the issues surrounding tablet sticking.
June 08, 2012
In addition to the established coating systems (like the BFC and the BFC TriPan), Bohle developed a new coater to face the market needs, the Bohle-Tablet-Coater BTC.
June 02, 2012
New coating technologies achieve high uniformity and reduce waste through mixing system advances and pan and airflow configuration.