Excipients

The use of appropriate taste-masking and appearance technologies can facilitate patient compliance.

A comparison between polysorbates and HPβCD determines the better stabilizer for biologics formulation.

Sara Fathollahi, PhD, product application specialist at DFE Pharma, makes the case of how excipient suppliers can support the transition from batch to continuous manufacturing.

A new generation of interactive formulation development platforms can leave trial and error in the formulation process in the past.

Colorcon provides customers with Opadry complete film coating systems, which intends to help reduce complexity with delivering high-quality products and ingredients.

Excipients should be treated equally when it comes to quality management, risk assessment, and testing.

Coprocessed excipients save time and cost while improving performance in a widening array of dosage forms.

Lipids aren’t the only important ingredients influencing stability and in vivo performance.

Impurities and batch-to-batch variability present the biggest challenges.

Lipids aren’t the only important ingredients influencing stability and in vivo performance.

High-concentration injectable formulations present unique challenges.

FDA has accepted Ashland’s Viatel bioresorbable mPEG-PDLLA pharmaceutical excipient into the FDA Novel Excipient Review Pilot Program.

Roquette has launched excipients PEARLITOL CR-H and PEARLITOL 200 GT.

The author discusses some new applications of TPGS in the pharmaceutical field that should see this versatile excipient retain its place in the drug formulators toolbox.

Roquette’s acquisition of Crest Cellulose is designed to reinforce its presence in India and other countries in Asia.

This article reviews sources of excipient variability, including raw materials and processing, both of which may vary from supplier to supplier and from plant to plant for a single manufacturer.

The right processes used with the right excipient combinations address evolving formulation needs.

Lubrizol has launched Apisolex technology to improve solubility and simplify the manufacturing of parenteral drug products.

Although not easy to do, it is essential because excipients can affect drug-product safety and efficacy.

Roquette is investing €25 million at its site in Lestrem, France to strengthen its position in the polyols market.

Dosage form and patient needs drive excipient choice.

Poor solubility remains a big issue for drug development and, as such, is driving innovation in approaches and use of novel technologies to help overcome the associated challenges.

Polymeric amorphous solid dispersions are the most commonly used technology, but amorphous APIs remain inherently unstable.

Gernot Warnke, Head of R&D, JRS Pharma, spoke about excipients and how these relate to feeding in batch and continuous manufacturing.

Advanced powder testing is a useful tool to differentiate materials and optimize the supply chain.

A new program will test the safety and suitability of new inactive ingredients to encourage the accelerated adoption of FDA-accepted excipients in drug development.

Consistency, robustness, and understanding of the API and controlled-release excipients are essential for successful drug dosing.

The potential for okra gum as a polymer candidate for new oral drug formulations was evaluated.

Advances in technology are accelerating the development and manufacture of subunit vaccines, an established class of vaccines.

Bi-layer tablets are an under-utilized option that can be employed to help reduce treatment burden, but their formulation is more complex than for conventional monolayer products.