Thermogelling Matrix-Containing Platelet Lysate-Loaded Elastic Liposomes as a Potential Treatment of Wounds

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This work focuses on the preparation, characterization, and evaluation of a thermogelling matrix of Pluronic F-127 containing elastic liposomes loaded with a platelet lysate and which is intended for healing wounds. In this study, elastic liposomes were characterized, and their biological activity was confirmed. Liposomes were obtained that had a high encapsulation rate. The formulation of liposomes in a thermogelling matrix based on Pluronic F-127 improved the properties of the product, favoring its application and retention on the skin, and promoting tissue regeneration, both on a culture of fibroblasts, and in vivo in mice. The results showed that this system is a potentially good alternative for the treatment of wounds based on its ability to protect the platelet lysate, allow its gradual release, produce a semi-occlusive effect on the skin, and promote fast tissue regeneration.

Peer-reviewed research

Submitted: Feb. 21, 2022
Accepted: June 9, 2022

About the authors

Sergio A. Bernal-Chávez, PhD, is research associate, and Adriana Ganem-Rondero*, PhD, ganemq@hotmail.com, is principal scientist; both at Laboratorio de Investigación y Posgrado en Tecnología Farmacéutica (L-322, Campo 1), Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México; Sergio Alcalá-Alcalá, PhD, is principal scientist at Laboratorio de Tecnología Farmacéutica, Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, México; and Doris Cerecedo, PhD, is principal scientist at Laboratorio de Hematobiología, Escuela Nacional de Medicina y Homeopatía, Sección de Estudios de Posgrado, Instituto Politécnico Nacional, Ciudad de México.

*To whom all correspondence should be addressed.

Article details

Pharmaceutical Technology
Vol. 46, No. 8
August 2022
Pages: 35–41

Citation

When referring to this article, please cite it as S.A. Bernal-Chávez, et al., “Thermogelling Matrix-Containing Platelet Lysate-Loaded Elastic Liposomes as a Potential Treatment of Wounds,” Pharmaceutical Technology 46 (8) 35–41 (2022).