Impact of Agitator Design on Bioreactor Performance

Publication
Article
Pharmaceutical TechnologyPharmaceutical Technology-05-15-2018
Volume 2018 eBook
Issue 1
Pages: 20–24

Aerobic bioprocesses are highly dependent upon the oxygen transfer rate (OTR) from sparged to dissolved gas. The relatively low solubility of oxygen, however, makes the choice of mixer impeller configuration a critical design factor for the bioreactor vessel. This article describes a series of experiments and computational fluid dynamics (CFD) simulations to detail the effect of mixer configuration on the efficiency and effectiveness of a bioreactor vessel with respect to blend time and mass transfer.

Aerobic bioprocesses are highly dependent upon the oxygen transfer rate (OTR) from sparged to dissolved gas. The relatively low solubility of oxygen, however, makes the choice of mixer impeller configuration a critical design factor for the bioreactor vessel. This article describes a series of experiments and computational fluid dynamics (CFD) simulations to detail the effect of mixer configuration on the efficiency and effectiveness of a bioreactor vessel with respect to blend time and mass transfer.

Read this article from Pharmaceutical Technology’s Biologics and Sterile Drug Manufacturing 2018 eBook.

Article Details

Pharmaceutical Technology
eBook: Biologics and Sterile Drug Manufacturing  
Vol. 42
May 2018
Pages: 20–24

Citation

When referring to this article, please cite it as A. Strand and N. Courtemanche, "Impact of Agitator Design on Bioreactor Performance," Pharmaceutical Technology Biologics and Sterile Drug Manufacturing eBook (May 2018).

About the Authors

Aaron Strand, PE is a senior research engineer with SPX FLOW, aaron.strand@spxflow.com; Nicolle Courtemanche is a senior application engineer with SPX FLOW, nicolle.courtemanche@spxflow.com.

Articles in this issue
Impact of Agitator Design on Bioreactor Performance
Impact of Agitator Design on Bioreactor Performance
Characterizing a Bioprocess with Advanced Data Analytics
Characterizing a Bioprocess with Advanced Data Analytics
Aseptic Transfer Technology: Weighing Up the Advantages of Varying Approaches for Sterile Drug Manufacturing
Aseptic Transfer Technology: Weighing Up the Advantages of Varying Approaches for Sterile Drug Manufacturing
Ready-to-Use Parenteral Packaging Components Address Evolving Aseptic Fill/Finish Requirements
Ready-to-Use Parenteral Packaging Components Address Evolving Aseptic Fill/Finish Requirements
Can Standards Help Pharma Modernize Lyophilization?
Can Standards Help Pharma Modernize Lyophilization?
Residual Moisture Testing Methods for Lyophilized Drug Products
Residual Moisture Testing Methods for Lyophilized Drug Products
Albumin Attachment Can Make Better Biobetters
Albumin Attachment Can Make Better Biobetters
Lies That Environmental Monitoring Systems Tell
Lies That Environmental Monitoring Systems Tell
Understanding Validation and Technical Transfer
Understanding Validation and Technical Transfer
New Technologies Streamline Fill/Finish Manufacturing
New Technologies Streamline Fill/Finish Manufacturing
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