Subathra Ramamoorthy, Veranova, on how forced degradation and trace impurity profiling in potent APIs shape regulator-ready analytical methods.
News|Articles|August 28, 2015
PTSM: Pharmaceutical Technology Sourcing and Management
- PTSM: Pharmaceutical Technology Sourcing and Management-09-02-2015
- Volume 11
- Issue 9
Flow Chemistry Systems Offer Options
Flow chemistry systems from Dolomite Microfluidics can be configured to suit different applications.
The Dolomite flow chemistry systems from Dolomite Microfluidics can be configured to suit different applications for education, continuous large-scale reactions, process optimization, scale-up and multi-step reactions.
The systems provide control of residence time, reaction temperature, stoichiometry and reagent introduction for performing detailed flow chemistry experiments. The systems include a choice of glass microreactors or tube reactors in PTFE or stainless steel from 2.5 µl up to 16 ml.
The TCU-125 Temperature Controller ensures accurate temperature control of chips from 1 to 125 °C, while the tube reactors can be heated from room temperatures to 250 °C using a hotplate. The Mitos Duo syringe pumps ensure smooth flow rates, from 1.0 µl/min to 10 ml/min, and allow use of the two syringes independently, or in one continuous flow, up to 6 bar.
Standard systems can be upgraded for additional functionality, such as reaction automation, continuous work-up, small-volume sample injection or pressurized inputs.
Source:
Articles in this issue
about 11 years ago
Technology Allows Automated Lab Reactor Controlabout 11 years ago
Spectrometers Comply with FDA Electronic Signature Regulationabout 11 years ago
Pressure Reactor for Small Batch Reaction Chemistryabout 11 years ago
Homogenizer Offers Continuous Operationabout 11 years ago
Mayne Pharma to Invest $65m in Manufacturing Expansionabout 11 years ago
Next Step for Elemental Impuritiesabout 11 years ago
WuXi PharmaTech Supplies Laboratory Testing Services to Lee's Pharmabout 11 years ago
Cytovance Biologics Acquired by Hepalinkabout 11 years ago
Industry Responds to FDA Metrics ProgramRelated to this article
Subathra Ramamoorthy, Veranova, on when to escalate to structural elucidation and pair orthogonal techniques when characterizing an impurity.
Nitin Kumar Swarnakar, PhD, global application lab manager at BASF, talks about spray drying for drying amorphous solid dispersions and Raman spectroscopy’s role as a quantitative analytical tool.
Nitin Kumar Swarnakar, PhD, global application lab manager at BASF in Tarrytown, spoke with PharmTech at AAPS PharmSci 360 about formulation and characterization challenges for amorphous solid dispersions.
FDA draft guidance on individualized genome editing lets BLAs add patient-specific variants without new trials, shifting evidence to CMC assay data.
Vibha Jawa, PhD, chief scientific officer at EpiVax, explains why the need for animal studies varies by modality and what it takes for organ-on-chip and other human-relevant models to replace these studies in IND-enabling toxicology work.
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