Pharmaceutical Technology Europe
- Pharmaceutical Technology Europe-12-01-2011
- Volume 23
- Issue 12
The Development of a Floating Drug-Delivery System for Metronidazole
The authors developed a metronidazole-based floating drug-delivery system to investigate the effect of rate-controlling polymers on release pattern and duration of buoyancy in matrix tablets.
By Shamsuddin Sultan Khan and Mesbah Uddin Talukder
Sustained-release dosage forms enable prolonged action of a drug in the body. Much research has focused on overcoming the short residence times and unpredictable gastric emptying times of drugs in sustained-release oral drug-delivery systems (1). A floating drug-delivery system floats in the gastric juice without affecting the gastric emptying rate. It forms a cohesive gel barrier that serves as a reservoir and releases the drug over the desired period of time. This technique helps increase a drug's gastric residence time and reduces the variability in bioavailability (2, 3).
This article was also published in our US sister publication Pharmaceutical Technology and can be read
Articles in this issue
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Mitigating Personnel Risksalmost 14 years ago
The Impact Of Single-Use Systemsalmost 14 years ago
Contamination: Invisible And Airbornealmost 14 years ago
Contract API Manufacturing: The Year in Reviewalmost 14 years ago
Avoiding Contamination Risks in Aseptic Processesalmost 14 years ago
Choosing Cleanroom Clothingalmost 14 years ago
The Employment Outlook Brightensalmost 14 years ago
It’s déjà vu all over againalmost 14 years ago
Newsalmost 14 years ago
Impact of AgeingNewsletter
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