Allergan Enters into Licensing Agreement with AstraZeneca
Allergan entered into a licensing agreement with AstraZeneca for MEDI2070, an anti-IL-23 monoclonal antibody in phase IIB development for the treatment of patients with moderate-to-severe Crohn’s disease.
On Oct. 3, 2016 Allergan announced that it has entered into a licensing agreement with MedImmune, AstraZeneca’s global biologics research and development arm, for the global rights to MEDI2070. MEDI2070 is an anti-IL-23 monoclonal antibody (mAb) currently in Phase IIB clinical development for the treatment of patients with moderate-to-severe Crohn’s disease. In a press announcement, Allergan said the mAb is Phase II ready for ulcerative colitis and other related inflammatory conditions.
Under the terms of the agreement, Allergan will make an upfront payment to AstraZeneca of $250 million for the exclusive license to develop and commercialize MEDI2070. Allergan may make potential payments to AstraZeneca of up to $1.27 billion, payable over a period of up to 15 years, including launch milestone payments of up to $435 million and sales-based milestone payments of $725 million, as well as tiered royalties on sales of the product. The transaction is expected to close in the fourth quarter of 2016.
MEDI2070 targets IL-23, which Allergan says may allow for a broader therapeutic window and better overall efficacy. MedImmune will continue the ongoing MEDI2070 Phase IIA study in Crohn’s disease to completion and will transition the Phase IIB study in Crohn’s disease to Allergan for completion.
Source: Allergan
Drug Solutions Podcast: Gliding Through the Ins and Outs of the Pharma Supply Chain
November 14th 2023In this episode of the Drug Solutions podcast, Jill Murphy, former editor, speaks with Bourji Mourad, partnership director at ThermoSafe, about the supply chain in the pharmaceutical industry, specifically related to packaging, pharma air freight, and the pressure on suppliers with post-COVID-19 changes on delivery.
