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The Use of Acrylic Resins for Improved Aqueous Enteric CoatingRecent technology improvements have made acrylics the preferred system for the aqueous enteric coating of tablets
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Preparing rapid disintegrating tablets containing taste-masking microgranulesThis article describes how rapidly disintegrating tablets containing a large quantity of an intensely bitter drug were successfully developed with a suitable level of masking, tablet hardness, disintegration property, dissolution profile and mouth feel.
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ICH seeks harmony on qualityThe International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) recently closed consultation on its draft guidance, ICH Q10 Pharmaceutical Quality System. If all goes to plan, adoption could come as soon as Spring 2008.
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Creating PVA copolymer capsulesWhen drugs are encapsulated, electrification (the electrostatic charge of the capsule) may sometimes cause problems, such as capsule adhesion during transportation or dispersion of the capsule content in the filling process.
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Stacking the chips against counterfeitsIs consolidated distribution the key to combating counterfeit drugs and parallel imports?
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Miniaturization of a Simulated Gastric Fluid Dispersion Experiment On a Microfluidics SystemThe miniaturization of preclinical safety assessment studies using a microfluidic chip system and optical microscopy can help reduce compound requirements, time, and costs in formulation development.
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Using Particle Size Analysis To Track The Granulation ProcessUse of in-process particle size analysis has enabled pharmaceutical scientists and process engineers to track the progress of a granulation process and detect its endpoint.
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Mixed-Flow Exhaust Technology: A New Approach for Energy Savings and Pollution AbatementRoof exhaust systems that incorporate mixed-flow impeller technology promote energy savings and cost containment.
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Applications of Raman spectroscopy in aqueous environmentsRaman spectroscopy has become a commonly used technique for physicochemical analysis that possesses many advantages over other analytical techniques. It is a very attractive characterization tool, not least because it enables measurements in water. However, very few examples of its application in an aqueous environment exist in literature. This paper provides some recent applications of Raman spectroscopy in pharmaceutical material and process characterization when water is present.
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Quick API deliveryThe authors consider the advantages of using rapidly dissolving films to accurately and effectively deliver pharmaceutical ingredients, with an emphasis on the importance of controlling moisture content and drug loading during formulation development.
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Packing-Line Improvement Based on a Fault-Tree Analysis ApproachThis article focuses on upgrading and improving a packing process to comply with current good manufacturing practices. The authors sought to maintain proper quality assurance for finished products.
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GDP comes to the foreThe recently published Orange Guide 2007 contains significant changes to the GMP requirement placed on pharmaceutical manufacturers, but there have been additional changes to good distribution practice that should not be overlooked.
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Innovation, Collaboration, and Technology Development - Leveraging the Thermo Fisher Ecosystem to Accelerate Platform Improvements in Biopharmaceutical ManufacturingThis PharmaTalks session focuses on how the integration of Patheon into Thermo Fisher Scientific has resulted in unique opportunities for innovation, collaboration, and technology development, and how we are leveraging the Thermo Fisher ecosystem to develop and improve a platform for biopharmaceutical manufacturing Live: Tuesday, May 19, 2020 at 8am EDT Register free
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FMEA toolThis downloadable Failure Mode Effect Analysis tool accompanies the article titled 'The Application of Quality by Design to Analytical Methods' by Phil Borman et. al.
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Multimodal HPLC screening of polysaccharide-based chiral stationary phasesHigh-performance liquid chromatography (HPLC) is a powerful tool for the enantioselective separation of chiral drugs. However, the selection of an appropriate chiral stationary phase (CSP) and suitable operating conditions is a bottleneck in method development and a time- and resource-consuming task. Multimodal screening of a small number of CSPs with broad enantiorecognition abilities has been recognized as the best strategy to achieve rapid and reliable separations of chiral compounds. This paper describes the generic screening strategy developed at Johnson & Johnson Pharmaceutical Research and Development to successfully develop enantioselective HPLC methods for chiral molecules of pharmaceutical interest.
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Optimizing bioconjugation processesThis article discusses a number of factors that may influence the behaviour of conjugated biopharmaceuticals. Optimizing bioconjugation processes may be critical to achieve the desired drug performance.
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The road to resource efficiencyHowever, companies should always be prioritizing prevention, elimination and reduction over recycling and recovery as the most effective ways of making resource efficiency savings.
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Growing the UK's bio cultureThe UK, with its high quality educational capabilities in bioscience, has an opportunity to become the global hub of bioscience training, but must act quickly to secure this position.
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Polymers for CNS drug deliveryThere is a tremendous need to enhance delivery of potential therapeutics to the brain for treatment of central nervous system (CNS) disorders. The blood brain barrier (BBB) restricts and controls the exchange of compounds between the CNS and the blood, which requires discovery of new modalities allowing for effective drug delivery to the CNS. Polymer nanotechnology has now become one of the most attractive areas of pharmaceutical research. This review focuses on the current progress in polymeric nanoparticles, where the specific arrangement of the polymeric matter at the nanoscale is utilized to design drug delivery systems that provide safe and efficient transport of CNS drugs across the BBB.
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Artificial intelligence the key to process understandingIn recent years, AI has become important in a number of fields in helping to make better use of information, increasing efficiency and enhancing productivity.
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Implications and Opportunities of Applying QbD Principles to Analytical MeasurementThe authors present two concepts to improve robustness and facilitate continuous improvement in analytical methods.
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Testing InhalersThis article investigates how the industry can test inhalers in a way that is most representative of typical use.
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Recovery of Precious Metals in Spent Process CatalystsCatalysts are important tools in the synthesis of active pharmaceutical ingredients. Recovery of precious-metal catalysts from a pharmaceutical manufacturing process is a factor in cost control and environmental compliance.
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Pure water technologyTraditionally, in pharmaceutical water systems the main method for controlling bacterial levels was heat or chemical sanitants...
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Quick API deliveryThe authors consider the advantages of using rapidly dissolving films to accurately and effectively deliver pharmaceutical ingredients, with an emphasis on the importance of controlling moisture content and drug loading during formulation development.
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Making drug production pain-freeThe more experienced contract manufacturers go far beyond superficial process improvements, drawing on their own expertise and resources to improve the service, value and flexibility they offer their clients.
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PS 9100:2002 Pharmaceutical Excipients - An Updated GMP Standard for Excipients SuppliersMedicines and excipients are inseparable, with few exceptions - one cannot exist without the other. The Pharmaceutical Quality Group and other international bodies have developed good manufacturing practice (GMP) standards and guidelines to facilitate the effective supply of excipients. This article discusses the definition and significance of excipients, and highlights the importance of implementing the correct excipient manufacturing controls and standards.
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Skin penetration of terpenesTerpenes are widely used in topical preparations. This paper focuses on the skin penetration of terpenes depending on their physicochemical properties and influence of the type of dermatological vehicle that was used. The structure of human skin and the skin penetration process is also briefly described.
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GDP comes to the foreThe recently published Orange Guide 2007 contains significant changes to the GMP requirement placed on pharmaceutical manufacturers, but there have been additional changes to good distribution practice that should not be overlooked.
