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Articles
Capping and Manufacturing Strategies for Increasing mRNA Potency and Reducing Costs
October 1st 2024In vitro transcription (IVT) is often used to make mRNA, and in co-transcriptional capping an analog cap can be used to cap the mRNA. This paper reviews the recent history of capping analogs in addition to a state-of-the-art approach to improve protein expression.
Chemically Modified mRNA as a Biologic: Developing an Analytical Framework for Success
October 5th 2022Wednesday, October 5, 2022 at 11:30am ET | 10:30am CT | 9:30am PT Developing an Analytical Framework for Success using a chemically modified mRNA can be compared with those for traditional biologics,. As such, it’s especially important that control on quality and consistency is maintained to ensure well characterized drug substance.
