Douglas C. Scott, PhD is a senior scientist at the Procter & Gamble company, Health Care Research Center, 8700 Mason-Montgomery Rd., Mason, Ohio 45040, tel. 513.622.2434, fax 513.622.2522.
Estimation of Distribution Coefficients from the Partition Coefficient and pKa
For a monovalent species, a simple calculation that does not assume partitioning of the ionized species in the oil phase can provide an accurate estimate of the distribution coefficient.