Daniel N. Hayes is associate principal scientist at Cambrex High Point Analytical Research and Development.
Utilizing Spectral Analysis in HPLC Diode Array to Discover Impurities
March 1st 2019Investigation of peak purity failure during HPLC method validation led to discovery of a co-eluting impurity under the main peak. Spectral analysis, including three-dimensional modelling, was used to characterize the peak, leading to the development of a new HPLC method for analysing impurity content.