Ali Nokhodchi, PharmD, PhD

Water interacts with pharmaceutical solids at virtually all stages of manufacture, from synthesis of raw materials to the storage of the final dosage form. The interactions of water with powders is, therefore, a major factor in the formulation, processing and product performance of solid pharmaceutical dosage forms.

Three methods for microencapsulating paracetamol using cellulose acetate phthalate as the coating agent revealed significant differences in terms of drug content, microcapsule size, and drug release rate.