Significantly improved analytical productivity with automated pretreatment operations
New i-Series Plus integrated HPLC
Shimadzu’s i-Series Plus expands the product line and improves performance and user-friendliness. With i-Series Plus, pretreatment operations have been automated, such as the processes to dilute samples and add reagents. This results in better reproducibility and measurement accuracy by minimizing human error, to ensure reliable data in the analysis of pharmaceuticals and foods. i-Series Plus also offers new features that satisfy data integrity requirements of the pharmaceutical industry. The i-Series Plus consists of the compact HPLC Prominence-i and UHPLC system Nexera-i.
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Diving Deep into Carrier-Based Formulation and Process Optimization
December 23rd 2024Carrier-based formulations for dry powder inhalers are carefully designed to transport extremely small particles into the lungs. Jet milling can be used to micronize these particles, with both high and low shear mixing processes used to formulate mixtures capable of carrying the fine API particles into the deep lung. This paper looks at the requirements for pulmonary delivery via carrier-based inhaled powder formulations, and how jet milling can be used to manufacture effective and stable materials for these formulations
Molecular Properties of PROTACs and the Relationship to Formulation Design
December 20th 2024Analyzation of a diverse set of PROTAC (Proteolysis Targeting Chimeras – a class of TPDs) structures and their calculated properties, identifying key structure-property trends that contribute to low oral bioavailability.
