PTSM: Pharmaceutical Technology Sourcing and Management
SAFC offers commercial and pilot-scale continuous-flow capacity.
SAFC Commercial, the custom manufacturing services business unit of Sigma-Aldrich, has installed a new commercial-scale continuous flow reactor at its Sheboygan, Wisconsin facility with capacity to produce up to 150 kg of product per day. Now fully operational, the reactor is complemented by a smaller pilot-scale continuous flow reactor that is being fabricated at the nearby Milwaukee, Wisconsin facility to carry out process optimization studies and manufacturing capability of up to 30 kg of product per day.
"These capabilities give customers access to products synthesized through reactions that were previously impractical or impossible to do with a conventional batch platform," said Andreas Weiler, director of global strategic marketing for SAFC, in a press release. "The reactors will allow SAFC to develop or scale up flow reactions for customers, eliminating the need for customers to install in-house flow capacity. This is also a much greener technology and substantially reduces the amount of chemicals and solvents employed in reactions."
Continuous flow manufacturing is a lean manufacturing platform that provides customers access to as little or as much of a product as needed. The nature of this technique offers safer, seamless scale-up of a wider array of reactions compared to the batch platform. Additionally, this technique may aid customers in achieving process control, while helping to eliminate batch failures and minimize risks associated with handling hazardous chemicals.
Source: Sigma-Aldrich
Drug Solutions Podcast: A Closer Look at mRNA in Oncology and Vaccines
April 30th 2024In this episode fo the Drug Solutions Podcast, etherna’s vice-president of Technology and Innovation, Stefaan De Koker, discusses the merits and challenges of using mRNA as the foundation for therapeutics in oncology as well as for vaccines.
Drug Solutions Podcast: Gliding Through the Ins and Outs of the Pharma Supply Chain
November 14th 2023In this episode of the Drug Solutions podcast, Jill Murphy, former editor, speaks with Bourji Mourad, partnership director at ThermoSafe, about the supply chain in the pharmaceutical industry, specifically related to packaging, pharma air freight, and the pressure on suppliers with post-COVID-19 changes on delivery.