PolyTherics and MacroGenics Extend ADC Collaboration

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ThioBridge linker technology to attach different payloads to a range of antibodies

PolyTherics, a technology solutions provider for biopharmaceutical development, has extended its antibody-drug conjugate (ADC) collaboration with US biotech company, MacroGenics. The extension follows the successful outcome of a research program undertaken in 2013 under a Research Collaboration and Option Agreement.

PolyTherics has developed ThioBridge for site-specific conjugation of cytotoxic payloads to antibodies to provide more stable and less heterogeneous ADCs. MacroGenics has two antibody technology platforms—a dual-affinity re-targeting (DART) bi-specific platform, in which a single recombinant molecule is able to target two different antigens, and Fc-optimized antibodies with improved effector function.

ThioBridge was used to conjugate a cytotoxic payload to a range of DART antibodies. MacroGenics and PolyTherics will collaborate in the application of its ThioBridge technology to a number of product candidates derived from MacroGenics’ antibody platforms.

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MacroGenics has an option to licence the ThioBridge technology for the development of these product candidates and PolyTherics would receive development milestones and a single-digit percentage royalty on sales of any ThioBridge ADC derived from this collaboration.

Source: PolyTherics