PolyTherics and MacroGenics Extend ADC Collaboration
ThioBridge linker technology to attach different payloads to a range of antibodies
PolyTherics, a technology solutions provider for biopharmaceutical development, has extended its antibody-drug conjugate (ADC) collaboration with US biotech company, MacroGenics. The extension follows the successful outcome of a research program undertaken in 2013 under a Research Collaboration and Option Agreement.
PolyTherics has developed ThioBridge for site-specific conjugation of cytotoxic payloads to antibodies to provide more stable and less heterogeneous ADCs. MacroGenics has two antibody technology platforms—a dual-affinity re-targeting (DART) bi-specific platform, in which a single recombinant molecule is able to target two different antigens, and Fc-optimized antibodies with improved effector function.
ThioBridge was used to conjugate a cytotoxic payload to a range of DART antibodies. MacroGenics and PolyTherics will collaborate in the application of its ThioBridge technology to a number of product candidates derived from MacroGenics’ antibody platforms.
MacroGenics has an option to licence the ThioBridge technology for the development of these product candidates and PolyTherics would receive development milestones and a single-digit percentage royalty on sales of any ThioBridge ADC derived from this collaboration.
Source: PolyTherics
Drug Solutions Podcast: Gliding Through the Ins and Outs of the Pharma Supply Chain
November 14th 2023In this episode of the Drug Solutions podcast, Jill Murphy, former editor, speaks with Bourji Mourad, partnership director at ThermoSafe, about the supply chain in the pharmaceutical industry, specifically related to packaging, pharma air freight, and the pressure on suppliers with post-COVID-19 changes on delivery.
