A new automated factory in Boston (MA, USA) has been developed that uses non-genetically modified green plants to quickly produce large quantities of vaccines and therapeutics.
A new automated factory in Boston (MA, USA) has been developed that uses non-genetically modified green plants to quickly produce large quantities of vaccines and therapeutics. The factory uses plant viral vector technology, developed by the Fraunhofer Center for Molecular Biotechnology (CMB) in Delaware for the biopharmaceutical company iBio, which when introduced into the plant, directs it to make a target protein. When this has accumulated in the plant's tissue, the biomass is harvested.
In a press statement, Vidadi Yusibov, Executive Director of CMB, said: "Traditional methods of vaccine production can take many months. Our plant-based technology provides the means for rapid, large-scale production of vaccine material in a cost-effective manner."
According to a press statement, the vaccines can be developed within weeks of an outbreak as the engineers have automated many aspects of traditional horticulture, including growing, watering and harvesting the plants using robotically engineered machines; in essence, turning a biological process into an industrial process. The factory has the capacity to grow tens of thousands of plants, and has been designed to be time-, cost- and space-efficient.
"In order to quickly produce large quantities of vaccine material or other protein-based medicines, such as antibodies, in compliance with cGMP, it was necessary to develop a consistent, repeatable process," Andre Sharon, a professor of mechanical engineering at Boston University and Director of the Fraunhofer Center for Manufacturing Innovation (CMI) in Boston, explained in the press statement. She also added that the vaccine production process can be safely and easily scaled up from a few milligrams to many kilograms. "The process is faster, cheaper, safer and does not require the sophisticated culturing or fermentation necessary in the current vaccine production process."
Drug Solutions Podcast: A Closer Look at mRNA in Oncology and Vaccines
April 30th 2024In this episode fo the Drug Solutions Podcast, etherna’s vice-president of Technology and Innovation, Stefaan De Koker, discusses the merits and challenges of using mRNA as the foundation for therapeutics in oncology as well as for vaccines.
PacBio Chosen as Tech Partner for Global Alzheimer’s Disease Research Project
April 23rd 2025The project, the North African Dementia Registry, will unite multiple entities for the purpose of developing a comprehensive dataset to advance the research community’s understanding of Alzheimer’s disease and other dementias in diverse populations.