Nexera Prep: Customer- and Application-Specific Solution

Nexera Prep: Customer- and Application-Specific Solution

Shimadzu’s Nexera Prep Series Preparative Purification Liquid Chromatograph (LC) provides better prep processes for extraction of functional and impurity components, as well as purification of target compounds in the pharmaceutical, chemical, and food industries. This product dramatically improves productivity via flexible scalability and an efficient, user friendly preparative workflow.

The Nexera Prep Series consists of multiple related products with the LC units as the core. Users select a pump, autosampler, and detector to build a system according to the purpose of the preparative work. Systems can be configured using related products such as the LH-40 Liquid Handler, FRC-40 Fraction Collector, Shim-pack Scepter LC Column for Analysis and Preparative Work, and Column Hub.

Preparative purification is generally performed following a multi-step workflow, which requires experience and time:

• Selection of system configuration and preparative column size based on the amount of purified sample or injection volume required

• Selection of fraction collector and container size according to the intended purpose

• Investigation of separation conditions in analytical scale

• Optimization of preparative LC conditions

• Confirmation of the purity of collected fractions

In addition to these steps, in some cases salts need to be removed or solvent needs to be evaporated after purification, requiring additional time and effort.

The Nexera Prep Series reduces the time spent on examining conditions using the software’s fractionation simulation function. It also enables simplified, fast operation in transition from analytical to preparative scale, with a column portfolio that covers a wide range of sizes. Furthermore, Shimadzu’s unique UFPLC (Ultra Fast Preparative and Purification LC) high-purity purification system reduces the time required for powderization via the elution of desalted target components with an organic solvent. This product satisfies a number of user demands, such as efficient desalting and powderization, multi-sample and multi-fraction analysis, effective separation at low cost, and the ability to check the purity.

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