Lubrizol Life Science Health partners with CONRAD to bring multipurpose IVR to the clinic
CONRAD is a biomedical research and development organization dedicated to improving the reproductive health of women, especially in developing countries. They have developed a first-in-class, multipurpose intravaginal ring (IVR) that combines levonorgestrel with tenofovir to provide contraception while preventing against acquisition of Human Immunodeficiency Virus (HIV) and Herpes Simplex Virus (HSV). To bring this novel concept into the clinic, CONRAD needed the support of a contract development and manufacturing organization (CDMO) with specialized expertise in long-acting implant and IVR development. Lubrizol Life Science – Health was able to provide CONRAD with comprehensive support throughout the project from technology transfer to manufacturing. Their experts were proactive and creative in streamlining manufacturing of the product, and they integrated quality control and assurance from the very beginning of the project. As a result, we helped CONRAD to bring a novel, life-changing product to the clinic, and they are committed to helping other organizations develop and commercialize innovative drug eluting devices (DED).
Molecular Properties of PROTACs and the Relationship to Formulation Design
December 20th 2024Analyzation of a diverse set of PROTAC (Proteolysis Targeting Chimeras – a class of TPDs) structures and their calculated properties, identifying key structure-property trends that contribute to low oral bioavailability.
Clinical Supply Planning in Europe - Balancing Cost, Flexibility and Time
December 19th 2024The packaging and distribution of clinical supplies is a fundamental piece to the overall success of a clinical trial, and advance preparation can help establish a more efficient supply chain. Selecting the best geographical location for those activities, however, depends on the clinical trial protocol, business decisions, and even the investigational medicinal product (IMP) being studied.
A Discussion: In Vitro Release Testing and Its Application and Use in Generic Topical
December 18th 2024Lucy Zhou, Skin Lab Manager, discusses the importance and applications for utilizing in vitro Release Testing during development of generic topical drug compounds. Lucy discusses how IVRT can play a critical role by saving cost and time during product development and the techniques and applications for using in vitro testing to achieve desired product outcomes.
