Improving Scalability of PLGA-based Drug Products for Parenteral Administration

This discussion dives into aspects of parenteral formulations containing the biodegradable polymer, poly (lactic-co-glycolic acid) “PLGA”. These aspects will provide an understanding of how to properly scale PLGA-based microparticles and in situ forming gel depots from lab to late-clinical phase. Scalability factors will be discussed, including manufacturing bottlenecks, particle generation techniques, sterility, and physical formulation aspects.

Register Free: https://www.pharmtech.com/pt_w/parenteral-administration

Event Overview:

This discussion dives into aspects of parenteral formulations containing the biodegradable polymer, poly (lactic-co-glycolic acid) “PLGA”. These aspects will provide an understanding of how to properly scale PLGA-based microparticles and in situ forming gel depots from lab to late-clinical phase. Scalability factors will be discussed, including manufacturing bottlenecks, particle generation techniques, sterility, and physical formulation aspects.

Key Learning Objectives:

Attendees will obtain a greater understanding of:

• Scalability of current poly (lactic-co-glycolic acid) formulations to meet manufacturing demand for both microparticle and in situ forming gel depots.
• Manufacturing routes for in situ gel depots and the effects of physical characteristics on sterility options.
• Future trends in PLGA-based parenteral products.

Who Should Attend:

• Formulation Scientists
• Research and Development (R&D) Scientists
• Clinical Trial Manufacturing Scientists and Operators
• Directors and Senior Directors of R&D
• Directors and Senior Directors of GMP Manufacturing

Speaker:

Matthew Owen, PhD
Scientist
Pace® Life Sciences

Matthew graduated with his BS in Chemistry from the University of California, Berkeley, where he primarily focused on inorganic/organic synthesis research. Following completion, he transitioned to the University of California, Davis, where he obtained his PhD in physical chemistry. His research was focused on drug delivery with industrial applications in long-acting injectables, like PLGA and dry-powder inhalables for pulmonary delivery. Immediately following completion of his PhD, he started working for Pace® Life Sciences, where he has continued to develop novel formulations and analytical methodologies for a wide range of applications.

Matt has a wife and three children. When he is not out with family, you can find him eagerly on the hunt to catch many different species of fish throughout California. Since moving to San Diego from Northern California, he loves the proximity to the ocean and the many varieties of Mexican and South American Cuisine.

Register Free: https://www.pharmtech.com/pt_w/parenteral-administration