Soluplus® delivers new levels of solubility and bioavailability for poorly soluble APIs. Exhibiting high flowability and extrudability, Soluplus® shows superior performance in forming solid solutions, especially in hot-melt extrusion processes.
Soluplus® the solid solution is an innovative excipient that enables new levels of solubility and bioavailability for poorly soluble active ingredients. Developed specifically for solid solutions, this easy-to-process polymer produces a significant improvement in API release.
Thanks to its high flowability and excellent extrudability, Soluplus® exhibits superior performance in forming solid solutions, especially in hot-melt extrusion processes. These solid solutions make the active pharmaceutical ingredient available in a dissolved state, leading to improved bioavailability once in the body. As a result, the polymer is opening new doors in the research and development of innovative pharmaceuticals.
Soluplus® is not limited to solid solutions formed via hot-melt extrusion, but can also be used as a matrix former in spray-drying processes. In addition, it can be deployed as a binder in wet or dry granulation and in drug layering.
A wide range of toxicological studies have been performed on Soluplus®, and the safety of the product has been comprehensively documented.
BASF Pharma Ingredients and Serviceswww.soluplus.compharma-ingredients@basf.com
Diving Deep into Carrier-Based Formulation and Process Optimization
December 23rd 2024Carrier-based formulations for dry powder inhalers are carefully designed to transport extremely small particles into the lungs. Jet milling can be used to micronize these particles, with both high and low shear mixing processes used to formulate mixtures capable of carrying the fine API particles into the deep lung. This paper looks at the requirements for pulmonary delivery via carrier-based inhaled powder formulations, and how jet milling can be used to manufacture effective and stable materials for these formulations