December 13th 2024
The partners will aim to establish a platform that enables rapid development of DPI products.
Controlling the Release of Highly Dosed and Highly Soluble Drugs
May 1st 2010The authors formulated bupropion hydrochloride tablets with various grades of methacrylic copolymers and analyzed the properties of the resulting dosage forms. This article is part of PharmTech's supplement "Solid Dosage and Excipients 2010."
Is Hot Melt Extrusion an Untapped Resource?
April 19th 2010If you’ve worked in the drug industry for a while, chances are good that you remember Pfizer’s Rezulin, which was produced through hot melt extrusion (HME). If you work for a major pharmaceutical manufacturer, it’s likely that your company owns a twin-screw extruder. Yet HME has not been a common way of manufacturing drugs, and many industry employees don’t understand the principles of HME or the advantages that the technique offers.
The Effect of Overencapsulation on Disintegration and Dissolution
April 2nd 2010The authors examined the disintegration and dissolution profiles of propranolol and rofecoxib tablets overencapsulated with standard hard-gelatin capsules and with capsules specifically designed for double-blind clinical trials.