PEGylation Reagents for Drug Delivery
Gelest, a manufacturer and provider of silane, silicone, and metal-organic compounds, released a range of dual-function poly(ethylene glycol) (PEG) reagents that enable new approaches to PEGylation for bioconjugates.
Gelest, a manufacturer and provider of silane, silicone, and metal-organic compounds, released a range of dual-function poly(ethylene glycol) (PEG) reagents that enable new approaches to PEGylation for bioconjugates, reduction of surface biofouling, and formation of polymerizeable vesicles for drug transport.
These materials are heterobifunctional with an amine at one terminus, and a choice of two different species at the other terminus. One species can undergo radical reactions, and the second species can undergo hydrolytic condensation.
In addition to reacting directly with appropriate functionality of drug or protein substrates, these materials have the potential to undergo polymerization, and to form polymerizeable vesicles, stabilizing PEGylated drugs or acting as co-monomers for microencapsulated drug delivery. The polymerization can proceed by either free-radical organic polymerization or hydrolysis-condensation siloxane polymerization.
Source: Gelest
Drug Solutions Podcast: A Closer Look at mRNA in Oncology and Vaccines
April 30th 2024In this episode fo the Drug Solutions Podcast, etherna’s vice-president of Technology and Innovation, Stefaan De Koker, discusses the merits and challenges of using mRNA as the foundation for therapeutics in oncology as well as for vaccines.
Drug Solutions Podcast: Gliding Through the Ins and Outs of the Pharma Supply Chain
November 14th 2023In this episode of the Drug Solutions podcast, Jill Murphy, former editor, speaks with Bourji Mourad, partnership director at ThermoSafe, about the supply chain in the pharmaceutical industry, specifically related to packaging, pharma air freight, and the pressure on suppliers with post-COVID-19 changes on delivery.
