Adare Pharmaceuticals: Improving solubility. Creating new possibilities for patients.

The bioavailability of a drug is strongly dependent on its solubility in the gastrointestinal tract. At Adare, we have proprietary technologies available to help improve the solubility of oral drugs.

Biorise™ Bioavailability Enhancement Technology

Biorise™ Bioavailability Enhancement Technology is used to enhance bioavailability of drugs that are poorly soluble at physiological pHs.

This technology creates new physical entities (NPEs) with better solubility profiles. These NPEs are produced by breaking down the crystalline drug into nanocrystals and/or amorphous (non-crystalline) drug particles that are stabilized in a carrier system to maintain the drug in its activated form for the duration of its shelf life.

This approach transforms the original crystalline form of the drug into an amorphous and/or nanocrystalline, thermodynamically activated solid form-characterized by higher solubility-thereby enhancing the rate and extent of absorption in the gastrointestinal tract.

With a broad range of proprietary technologies, Adare can help you overcome formulation challenges. To learn more about Biorise™ Bioavailability Enhancement Technology and our other proprietary technologies, contact Lisa.Miller@adarepharma.com or visit www.AdarePharma.com.

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