Whitepapers - Pharmaceutical Technology

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Whitepapers

  • Magnetic Mixers: How Are They Different?


    Magnetic mixers are known to offer significant processing advantages over other types of mixers. This white paper touches on those differences, but focuses heavily on the differences between the different magnetic mixer designs. It highlights some of the most common issues with magnetic mixing, and how one mixer has overcome these issues.

    Fire-rated pallets: What you need to know


    This paper attempts to identify some of the specifics of the process used to obtain approval for use of plastic pallets as equivalent to wood pallets for use in warehouse storage. This paper is written to look at the issue in general and is not intended to cover all storage situations. Your specific situation should be evaluated by a fire protection specialist.

    Developing powder processing expertise for the implementation of Quality by Design


    Powder characterization techniques have improved significantly in recent decades, developing well beyond the simplistic methods traditionally used. This paper examines the changes in approach encouraged by QbD and the contribution modern powder testers can make.

    Final Bulk Inspection of Solid-Dose Pharmaceuticals


    Final bulk inspection of solid-dose OTC and regulated pharmaceuticals must deliver consistently high product quality. Customers scrutinize products closely, and processes are increasingly coming under the review of regulatory agencies. Advanced technology addresses these challenges, as new automated continuous inspection systems are more effective and commercially viable than ever before.

    Containment of Basket Filtration Centrifuges


    Basket filtration centrifuges are commonly used as a means of filtering potent compounds, and are an effective way to separate and purify solid products. As the demands to minimize operator exposure to the products increase, and as the exposure limits to solvent vapors decrease, the challenge with basket filtration centrifuges is to maintain contained transfer of the caked solids during discharge into downstream processing equipment.

    Wireless Environmental Monitoring Solutions


    This paper describes the advantages of using a wireless environmental monitoring system for measuring humidity and temperature parameters in manufacturing and process industries. It explains the ease of installation procedure and answers the safety and data security concerns that often influence a purchase decision.

    Scale-up of Liquid / Liquid Centrifuges


    Centrifugal contactors are one of the technologies employed for liquid / liquid separation and liquid / liquid extraction processes. Every liquid / liquid system has its own specific characteristics and in order to successfully predict behavior, testing must be performed with small scale equipment to predict industrial performance. Process intensification studies can be performed using laboratory scale centrifugal contactors to evaluate these parameters. Pilot scale testing is performed with larger equipment to perform more thorough and specific testing.

    In Situ Monitoring of CHO Cell Culture Medium Using NIR Spectroscopy


    NIR spectroscopy using specialized transmission probes and fiber optics allows real-time in situ analysis of bioreactor feed stocks and product. With continuous NIR analysis, metabolic parameters and culture media constituents can be better monitored and controlled, which increases CHO cell life and lengthens the production phase.

    Monitoring Granulation Drying using Near-Infrared Spectroscopy


    In situ analysis of residual moisture and methanol using Near-Infrared (NIR) Spectroscopy. A novel probe design can reduce the powder-sample density variance such that moisture and solvent levels can be accurately modeled and predicted in process. NIR can monitor low levels of residual moisture, alcohol and other process constituents to yield better process control and quality management.

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